AI Article Synopsis
- - The study focuses on creating new semi-synthetic versions of deoxycholic acid (DCA) with specific chemical modifications in two of its rings.
- - These modified compounds were tested for their biological activity against cancer cells and murine macrophage-like cells.
- - Results indicate that adding a 9(11)-double bond or an isoxazole ring enhances the compounds' effectiveness in inhibiting cancer cell growth.
Article Abstract
We report the synthesis and biological activity of new semi-synthetic derivatives of naturally occurring deoxycholic acid (DCA) bearing 2-cyano-3-oxo-1-ene, 3-oxo-1(2)-ene or 3-oxo-4(5)-ene moieties in ring A and 12-oxo or 12-oxo-9(11)-ene moieties in ring C. Bioassays using murine macrophage-like cells and tumour cells show that the presence of the 9(11)-double bond associated with the increased polarity of ring A or with isoxazole ring joined to ring A, improves the ability of the compounds to inhibit cancer cell growth.
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| http://dx.doi.org/10.1016/j.bmc.2015.05.012 | DOI Listing |
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