The relationship between body mass index and uric acid: a study on Japanese adult twins.

Environ Health Prev Med

Department of Community Health Nursing, Gifu University School of Medicine, 1-1 Yanagido, Gifu City, Gifu, 501-1194, Japan,

Published: September 2015

AI Article Synopsis

  • The study explored how body mass index (BMI) relates to uric acid (UA) levels, using twins to account for genetic influences.
  • Data was collected from 422 twins at Osaka University between 2011 and 2014, measuring various health indicators and using advanced statistical methods to analyze the results.
  • Findings indicated a significant association between BMI and UA in both men and women, even after adjusting for genetic and family environmental factors.

Article Abstract

Objectives: The present study aimed to investigate the association between body mass index (BMI) and uric acid (UA) using the twin study methodology to adjust for genetic factors.

Methods: The association between BMI and UA was investigated in a cross-sectional study using data from both monozygotic and dizygotic twins registered at the Osaka University Center for Twin Research and the Osaka University Graduate School of Medicine. From January 2011 to March 2014, 422 individuals participated in the health examination. We measured height, weight, age, BMI, lifestyle habits (Breslow's Health Practice Index), serum UA, and serum creatinine. To investigate the association between UA and BMI with adjustment for the clustering of a twin within a pair, individual-level analyses were performed using generalized linear mixed models (GLMMs). To investigate an association with adjustment for genetic and family environmental factors, twin-pair difference values analyses were performed.

Results: In all analysis, BMI was associated with UA in men and women. Using the GLMMs, standardized regression coefficients were 0.194 (95 % confidence interval: 0.016-0.373) in men and 0.186 (95 % confidence interval: 0.071-0.302) in women. Considering twin-pair difference value analyses, standardized regression coefficients were 0.333 (95 % confidence interval: 0.072-0.594) in men and 0.314 (95 % confidence interval: 0.151-0.477) in women.

Conclusions: The present study shows that BMI was significantly associated with UA, after adjusting for both genetic and familial environment factors in both men and women.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4550610PMC
http://dx.doi.org/10.1007/s12199-015-0473-3DOI Listing

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