AI Article Synopsis
- - A new method was created to selectively form intermediates for making C1 substituted carbapenems, which are types of antibiotics.
- - This process stands out because it can be easily scaled up for large production and doesn’t use complex chemicals like organometallics or strong bases.
- - This advancement could potentially simplify the production of important pharmaceutical compounds.
Article Abstract
A diastereoselective process for the formation of intermediates suitable for the preparation of C1 substituted carbapenems was developed. The process is readily scalable and does not involve organometallics or strong bases such as LDA.
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Source |
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4448756 | PMC |
| http://dx.doi.org/10.1016/j.tetlet.2015.01.025 | DOI Listing |
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Triethysilyl Enol Ethers in the Synthesis of Carbapenem Precursors.
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Department of Chemistry, Southern Methodist University, Dallas, TX 75275 ; Center for Drug Discovery, Design, and Delivery, Dedman College, Southern Methodist University, Dallas, TX 75275.
Article Synopsis
- - A new method was created to selectively form intermediates for making C1 substituted carbapenems, which are types of antibiotics.
- - This process stands out because it can be easily scaled up for large production and doesn’t use complex chemicals like organometallics or strong bases.
- - This advancement could potentially simplify the production of important pharmaceutical compounds.
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