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Microbiome Differences in Colorectal Cancer Patients and Healthy Individuals: Implications for Vaccine Antigen Discovery.
Immunotargets Ther
December 2024
Department of Pharmaceutical Sciences, North Carolina Central University, Durham, NC, 27707, USA.
Background: Colorectal cancer (CRC) is the third most prevalent cancer worldwide, with numerous risk factors contributing to its development. Recent research has illuminated the significant role of the gut microbiota in CRC pathogenesis, identifying various microbial antigens as potential targets for vaccine development.
Aim: This review aimed at exploring the potential sources of microbial antigens that could be harnessed to create effective CRC vaccines and understand the role of microbiome-CRC interactions in carcinogenesis.
Baicalein disrupts the KEAP1-NRF2 interaction to alleviate oxidative stress injury by inhibiting M1 macrophage polarization.
Free Radic Biol Med
December 2024
State Key Laboratory of Medicinal Chemical Biology, College of Pharmacy and Tianjin Key Laboratory of Molecular Drug Research, Nankai University, Tianjin, 300353, China. Electronic address:
Macrophages are key players in maintaining the balance of tissues and dealing with inflammation, carrying out vital functions specific to different tissues while safeguarding the body against infections. The intricate interplay between oxidative stress and macrophage polarization and how this contributes to pneumonia is not fully understood. Herein, a predominant accumulation of baicalein in lung macrophages of pathogen-infected mice was observed by an alkynyl-modified probe.
View Article and Find Full Text PDFSex and Body Mass Index Differences in Changes in Skin Temperature After Repeated Sessions of Whole-Body Cryostimulation.
J Clin Med
December 2024
Research Laboratory in Biomechanics, Rehabilitation and Ergonomics, IRCCS Istituto Auxologico Italiano, San Giuseppe Hospital, 28824 Verbania, Italy.
: Whole-body cryostimulation (WBC) involves exposure to extremely low temperatures to reduce inflammation and pain and to enhance recovery. Despite its growing popularity and the importance of the magnitude of WBC-induced skin cooling in triggering the cascade of effects, limited research has focused on skin temperature changes in individuals with severe obesity, where body composition and sex may influence outcomes. : To examine differences in the cooling response based on sex and BMI, we conducted an observational study comparing patients with obesity to normal-weight individuals after repeated WBC sessions.
View Article and Find Full Text PDFAssessment of corticospinal tract damage and cytokines response in early and late stages of acute unilateral brainstem infarction patients.
Front Immunol
December 2024
Department of Radiology, Nanjing First Hospital, Nanjing Medical University, Nanjing, China.
Background: Acute brainstem infarction is associated with high morbidity and mortality, the integrity of corticospinal tract (CST) detected via diffusion tensor imaging (DTI) can assist in predicting the motor recovery of the patients. In addition to the damage caused by ischemia and reperfusion, sterile inflammation also contributes to the brain injury after stroke. However, the changes in CST integrity detected by DTI in acute brainstem infarction have yet to be fully elucidated, and it is still unclear whether sterile inflammation can cause damage to the CST.
View Article and Find Full Text PDFUnderstanding the mechanisms of in penetrating the blood-brain barrier: insights into bacterial binding with central nervous system host receptors.
Tissue Barriers
December 2024
Department of Biomedical Sciences, Faculty of Medicine & Health Sciences, Universiti Putra Malaysia, Serdang, Malaysia.
This review investigates the pathogenic processes through which crosses the blood-brain barrier (BBB) to cause meningitis, with a focus on the interaction with host receptors in the central nervous system (CNS). a primary cause of bacterial meningitis, utilizes unique receptor-mediated pathways to infiltrate the BBB. The bacterial interaction with the platelet-activating factor receptor (PAFR) and the polymeric immunoglobulin receptor (pIgR) is looked at in this study.
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