Link et al. (2010, Biometrics 66, 178-185) define a general framework for analyzing capture-recapture data with potential misidentifications. In this framework, the observed vector of counts, y, is considered as a linear function of a vector of latent counts, x, such that y=Ax, with x assumed to follow a multinomial distribution conditional on the model parameters, θ. Bayesian methods are then applied by sampling from the joint posterior distribution of both x and θ. In particular, Link et al. (2010) propose a Metropolis-Hastings algorithm to sample from the full conditional distribution of x, where new proposals are generated by sequentially adding elements from a basis of the null space (kernel) of A. We consider this algorithm and show that using elements from a simple basis for the kernel of A may not produce an irreducible Markov chain. Instead, we require a Markov basis, as defined by Diaconis and Sturmfels (1998, The Annals of Statistics 26, 363-397). We illustrate the importance of Markov bases with three capture-recapture examples. We prove that a specific lattice basis is a Markov basis for a class of models including the original model considered by Link et al. (2010) and confirm that the specific basis used in their example with two sampling occasions is a Markov basis. The constructive nature of our proof provides an immediate method to obtain a Markov basis for any model in this class.
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http://dx.doi.org/10.1111/biom.12333 | DOI Listing |
Cogn Neurodyn
December 2025
The Medical Big Data Research Center, Northwest University, Xi'an, 710127 China.
Insomnia, as a common sleep disorder, is the most common complaints in medical practice affecting a large proportion of the population on a situational, recurrent or chronic basis. It has been demonstrated that, during wakefulness, patients with insomnia exhibit increased EEG power in theta, beta, and gamma band. However, the relevant mechanisms underlying such power changes are still lack of understanding.
View Article and Find Full Text PDFClin J Am Soc Nephrol
January 2025
Division of Nephrology and Endocrinology, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan.
Key Points: Empagliflozin is cost-effective for the treatment of CKD in patients with an urine albumin-to-creatinine ratio of 30 mg/g or more. Empagliflozin is not cost-effective for the treatment of CKD in patients with an urine albumin-to-creatinine ratio <30 mg/g.
Background: The Study of Heart and Kidney Protection with Empagliflozin (EMPA-KIDNEY) expanded the CKD population that may benefit from sodium-glucose cotransporter 2 inhibitors in terms of eGFR and urine albumin-to-creatinine ratio.
Plants (Basel)
December 2024
College of Grassland Science, Qingdao Agricultural University, Qingdao 266109, China.
The gene family plays a crucial role in plant growth, development, and responses to biotic and abiotic stresses. , a warm-season turfgrass with exceptional salt tolerance, can be irrigated with seawater. However, the gene family in seashore paspalum remains poorly understood.
View Article and Find Full Text PDFSci Rep
January 2025
College of Post and Telecommunication, Wuhan Institute of Technology, Wuhan, 430073, China.
Commun Chem
December 2024
Department of Chemical and Biomolecular Engineering, University of Illinois at Urbana-Champaign, Urbana, IL 61801, USA.
The PepT transporter mediates the transport of peptides across biological membranes. Despite advancements in structural biology, including cryogenic electron microscopy structures resolving PepT in different states, the molecular basis of peptide recognition and transport by PepT is not fully elucidated. In this study, we used molecular dynamics simulations, Markov State Models (MSMs), and Transition Path Theory (TPT) to investigate the transport mechanism of an alanine-alanine peptide (Ala-Ala) through the PepT transporter.
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