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Early and delayed STAT1-dependent responses drive local trained immunity of macrophages in the spleen.
Elife
January 2025
Department of Immunology and Regenerative Biology, Weizmann Institute of Science, Rehovot, Israel.
Trained immunity (TI) is the process wherein innate immune cells gain functional memory upon exposure to specific ligands or pathogens, leading to augmented inflammatory responses and pathogen clearance upon secondary exposure. While the differentiation of hematopoietic stem cells (HSCs) and reprogramming of bone marrow (BM) progenitors are well-established mechanisms underpinning durable TI protection, remodeling of the cellular architecture within the tissue during TI remains underexplored. Here, we study the effects of peritoneal Bacillus Calmette-Guérin (BCG) administration to find TI-mediated protection in the spleen against a subsequent heterologous infection by the Gram-negative pathogen Typhimurium (.
View Article and Find Full Text PDFPeritonitis-related bacterial infections: a large-scale case-series retrospective study in 160 domestic animals (2009-2022).
Braz J Microbiol
December 2024
Department of Animal Production and Preventive Veterinary Medicine, Faculty of Veterinary Medicine and Animal Sciences- FMVZ, Infectious Diseases of Domestic Animals, Sao Paulo State University - UNESP, Botucatu, SP, 18618-681, Brazil.
Bacterial peritonitis infections comprise a life-threatening clinical condition in domestic animals that commonly lead to sepsis and high mortality. A set of bacterial pathogens have been identified in septic peritonitis in livestock and companion animals. Nonetheless, most descriptions are restricted to case reports or limited to only one domestic species, and a restrict number of comprehensive studies involving this infection has focused on a great number of domestic animals.
View Article and Find Full Text PDFIncreasing trends of antibiotic resistance in Uganda: analysis of the national antimicrobial resistance surveillance data, 2018-2021.
BMC Infect Dis
September 2024
National Health Laboratory and Diagnostic Services Department, Ministry of Health, Kampala, Uganda.
Article Synopsis
- The study evaluated antimicrobial resistance (AMR) trends in Uganda by analyzing bacterial isolates from clinical samples between 2018-2021 to improve public health responses.
- A total of 537 isolates were analyzed, with Staphylococcus aureus and Salmonella being the predominant pathogens, showing significant resistance to various antibiotics, particularly sulfonamides and fluoroquinolones.
- The results indicated fluctuating resistance levels, particularly in methicillin-resistant Staphylococcus aureus and increasing resistance among gram-negative bacteria to antibiotics like tetracycline and ceftriaxone.
Bacterial Prostatitis Secondary to Salmonella enterica serovar Enteritidis in an Immunocompetent Dog.
J Am Anim Hosp Assoc
September 2024
School of Veterinary Medicine, University of Pennsylvania, Philadelphia, Pennsylvania (S.C.).
Salmonella is a rod-shaped gram-negative bacterium of the family Enterobacteriaceae, commonly present in the gastrointestinal tract in humans and animals. Salmonella-associated bacteriuria and prostatitis are rare but have been reported in humans, predominantly older patients with underlying diseases, including urinary tract obstructions, diabetes mellitus, and compromised immunity. In dogs, Salmonella bacteriuria and prostatitis have only been described in patients on immunosuppressive medications.
View Article and Find Full Text PDFSalmonella Peritonitis Secondary to Gastroduodenal Perforation: An Unusual Presentation of Enteric Fever.
Cureus
July 2024
Department of Microbiology, Saveetha Medical College and Hospitals, Saveetha Institute of Medical and Technical Sciences, Saveetha University, Chennai, IND.
-induced peritonitis, secondary to spontaneous gastrointestinal perforation, is a rare but potentially life-threatening condition. We present a case of a 62-year-old female with a history of systemic hypertension, who presented with diffuse abdominal pain and altered bowel habits. Initial evaluation suggested acute gastroenteritis, but worsening symptoms led to emergent exploratory laparotomy, revealing a gastric/duodenal perforation.
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