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Therapeutic hypoglycemic potential of Pentapetes phoenicea L. in experimentally induced hyperglycemic rats. | LitMetric

AI Article Synopsis

  • Diabetes mellitus is a widespread metabolic disorder posing serious health risks globally, leading researchers to explore plant-based alternatives for blood sugar management.
  • The study investigated the hypoglycemic effects of a 70% alcoholic extract of Pentapetes phoenicea on blood glucose levels in various types of rats, including those with induced diabetes.
  • Results showed that the extract significantly lowered blood glucose levels in a dose-dependent manner compared to the synthetic drug glibenclamide, indicating its potential as a natural treatment due to its active compounds like tannins and flavonoids.

Article Abstract

Diabetes mellitus is a metabolic disorder of endocrine system. This dreadful disease is found all over the world and is becoming a serious threat to the mankind health. Alternative to synthetic agents, plants provide a potential source of hypoglycemic drugs. The aim of the present study was to evaluate the hypoglycemic effect of 70% alcoholic extract of Pentapetesphoenicea (PPE) on blood glucose level in glucose loaded, normal and experimentally induced diabetic rats. Based on the acute toxicity test, two variable doses (250, 500 mg kg(-1) b.wt.) of hydro-alcoholic extract of P. phoenicea leaves were compared with glibenclamide for the influence on fasting blood glucose in glucose loaded, normoglycemic and streptozotocin (STZ) (55 mg kg(-1), i.p.) induced hyperglycemic rats. All the statistical comparisons were made by one-way analysis of variance (ANOVA) followed by Newman-Keuls Multiple Comparison Test using Graph Pad Prism 4.01 v for windows (Graph Pad Software, San Diego, CA, USA). The difference showing a p level of 0.05 or lower was considered to be statistically significant. The administration of PPE in two doses and glibenclamide (5 mg kg(-1)) to STZ induced hyperglycemic animals significantly lowered the blood glucose levels with 18.84% (p<0.01) for PPE 250 mg kg and 38.89% (p<0.001) for PPE 500 mg kg(-1) in a dose dependant manner. Considering all the results obtained, the study concludes that the hydro-alcoholic extract of P. phoenicea leaves produced promising decrease in blood glucose levels in STZ induced hyperglycemic rats which might be related to tannins, terpenoids, sterols and flavonoid contents.

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Source
http://dx.doi.org/10.3923/pjbs.2014.709.714DOI Listing

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