AI Article Synopsis
- - This research focuses on pituitary adenoma, a common brain tumor, and aims to uncover its genetic origins through a genome-wide association study (GWAS) in the Han Chinese population.
- - The study involved analyzing genetic data from over 3,000 people with pituitary adenoma and thousands of controls to identify variants associated with the disease.
- - Researchers discovered three new genetic loci that may make people more susceptible to sporadic pituitary adenoma, providing valuable insights into its genetic basis for future studies.
Article Abstract
Pituitary adenoma is one of the most common intracranial neoplasms, and its genetic basis remains largely unknown. To identify genetic susceptibility loci for sporadic pituitary adenoma, we performed a three-stage genome-wide association study (GWAS) in the Han Chinese population. We first analyzed genome-wide SNP data in 771 pituitary adenoma cases and 2,788 controls and then carried forward the promising variants for replication in another 2 independent sets (2,542 cases and 3,620 controls in total). We identified three new susceptibility loci below the genome-wide significance threshold (P < 5 × 10(-8)) in the combined analyses: 10p12.31 (rs2359536, P(meta) = 2.25 × 10(-10) and rs10828088, P(meta) = 6.27 × 10(-10)), 10q21.1 (rs10763170, P(meta) = 6.88 × 10(-10)) and 13q12.13 (rs17083838, P(meta) = 1.89 × 10(-8)). This study is the first GWAS to our knowledge on sporadic pituitary adenoma, and our results provide insight into the genetic basis of this disease.
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| http://dx.doi.org/10.1038/ng.3322 | DOI Listing |
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