In 1946 General Dwight Eisenhower, the Army Chief of Staff, established the Research and Development (R&D) Division on the War Department General Staff to expedite major technological breakthroughs in weapons technology. This goal, based on the separation of the management of R&D from procurement, captured the Army's preference for qualitative rather than quantitative superiority on the battlefield, but it threatened to upend entrenched methods of incremental product improvement under way in the Army's supply organizations, collectively called the technical services. The division's brief existence (it ceased operations in 1947) contrasted sharply with the longevity of the Ordnance Department's in-house manufacturing arsenals; for more than a century they had exploited synergies between R&D and production to turn out new weapons mass-produced in industry. The history of the R&D Division and the corresponding management of technological innovation in the technical services broadens an otherwise narrow historiographical interpretation of postwar knowledge production in the United States that is still focused heavily on the moral and political economy of military-funded academic research.
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http://dx.doi.org/10.1086/681038 | DOI Listing |
ACS Appl Bio Mater
January 2025
Department of Applied Chemistry, Rajiv Gandhi Technological University, Bhopal 462033, Madhya Pradesh, India.
Deciphering the most promising strategy for the evolution of cancer patient management remains a multifaceted, challenging affair to date. Additionally, such approaches often lead to microbial infections as side effects, probably due to the compromised immunity of the patients undergoing such treatment. Distinctly, this work delineates a rational combinatorial strategy harnessing stereogenic harmony in the diphenylalanine fragment, tethering it to an amphiphile 12-hydroxy-lauric acid at the N-terminus (compounds -) such that a potential therapeutic could be extracted out from the series.
View Article and Find Full Text PDFFuture Med Chem
January 2025
Postgraduate Program in Pharmaceutical Sciences, Federal University of Sergipe, São Cristóvão, Brazil.
Flavonoids such as silibinin, hesperetin, and phloretin exhibit well-documented biological activities, including anti-inflammatory, cytoprotective, anticarcinogenic, and antioxidant effects. However, their clinical application remains limited due to challenges such as poor aqueous solubility, low bioavailability, and restricted intestinal absorption, which can significantly reduce their pharmacological efficacy. This review analyzed patents related to innovative pharmaceutical technologies for flavonoids.
View Article and Find Full Text PDFNeurogastroenterol Motil
January 2025
Department of Neurology, The Third Xiangya Hospital, Central South University, Changsha, Hunan, China.
Background: Constipation is one of the most common non-motor symptoms in patients with Parkinson's disease (PD), which could manifest during the early stage of the disease. However, the etiology of constipation in PD remains largely unknown. Previous studies supported that gastrointestinal dysfunction may be associated with functional connectivity alterations in paraventricular hypothalamic nucleus (PVN).
View Article and Find Full Text PDFFront Public Health
January 2025
School of Naval Architecture, Ocean and Energy Power Engineering, Wuhan University of Technology, Wuhan, China.
Introduction: This article explores the impact of innovation on urban public health, with a particular focus on panel data from 15 sub-provincial cities in China. The study aims to provide scientific evidence for policymakers by analyzing how technological innovation affects urban public health levels.
Methods: The study used a panel model for empirical analysis which based on panel data from 15 sub provincial cities across the country, using the number of doctors per 10,000 people and per capita financial medical and health expenditure as proxy variables for urban public health, and using the level of technological development as the core explanatory variable for regression analysis.
Front Digit Health
January 2025
Health Sciences Graduate Program, Federal University of Rio Grande do Norte, Natal, Brazil.
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