AI Article Synopsis
- Testicular germ cell tumor (TGCT) is the most common testicular cancer, with rising rates and unclear causes.
- Next-generation sequencing helps researchers understand TGCT's mechanisms by examining gene expressions, mutations, and pathways linked to its development.
- Recent genomics studies aim to identify key pathogenic genes, which could enhance early detection and targeted treatments for TGCT.
Article Abstract
Testicular germ cell tumor (TGCT) is a most common testicular malignancy with an increasing incidence, and its pathogenesis and mechanisms are not yet clear. The next generation sequencing has become the main tool to uncover the underlying mechanisms of TGCT. The differential gene expressions, gene mutation, predisposing gene-dominated signaling pathways, and changes of the relevant genes in the sex chromosome are largely involved in the occurrence and development of TGCT. Studies on the genomics of TGCT contribute a lot to identifying the pivotal pathogenic genes and paving a theoretical ground for the early screening and targeted therapy of TGCT. This paper summarizes the advances in the studies of the genomics of TGCT so as to reveal thetmechanisms of the disease at the genetic level.
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