A diagnostic tool for precise alignment of targets in laser-matter interactions based on confocal microscopy is presented. This device permits precision alignment of targets within the Rayleigh range of tight focusing geometries for a wide variety of target surface morphologies. This confocal high-intensity positioner achieves micron-scale target alignment by selectively accepting light reflected from a narrow range of target focal planes. Additionally, the design of the device is such that its footprint and sensitivity can be tuned for the desired chamber and experiment. The device has been demonstrated to position targets repeatably within the Rayleigh range of the Scarlet laser system at The Ohio State University, where use of the device has provided a marked increase in ion yield and maximum energy.

Download full-text PDF

Source
http://dx.doi.org/10.1063/1.4921554DOI Listing

Publication Analysis

Top Keywords

micron-scale target
8
target alignment
8
alignment targets
8
rayleigh range
8
confocal microscope
4
microscope position
4
position sensor
4
sensor micron-scale
4
target
4
alignment
4

Similar Publications

Eukaryotic nuclei adopt a highly compartmentalized architecture that influences nearly all genomic processes. Understanding how this architecture impacts gene expression has been hindered by a lack of tools for elucidating the molecular interactions at individual genomic loci. Here, we adapt oligonucleotide-mediated proximity-interactome mapping (O-MAP) to biochemically characterize discrete, micron-scale nuclear neighborhoods.

View Article and Find Full Text PDF

Quantitative Particle Analysis of Neptunium-237 Oxides: Optimization of MAMA Analysis for Modified Direct Denitration Products.

Microsc Microanal

November 2024

Radioisotope Science and Technology Division, Oak Ridge National Laboratory, Oak Ridge, TN 37830, USA.

The production of plutonium-238 through irradiation of neptunium-237 (237Np) target materials for the use in radioisotope thermoelectric generators is paramount for continued deep space exploration. This work employs scanning electron microscopy to analyze 237Np materials coupled with a well-developed image analysis framework (Morphological Analysis for Material Attribution, or MAMA) to determine the degree of micron-scale homogeneity in the materials. This work demonstrated how the quantification of particle characteristics can validate production materials and affirm the qualitative similarities observed in micrographs.

View Article and Find Full Text PDF

In super-resolution, a varying illumination image stack is required. This enriched dataset typically necessitates precise mechanical control and micron-scale optical alignment and repeatability. Here, we introduce a novel methodology for super-resolution microscopy called stochastically structured illumination microscopy (SIM), which bypasses the need for illumination control exploiting instead the random, uncontrolled movement of the target object.

View Article and Find Full Text PDF
Article Synopsis
  • Ferroptosis is a significant factor in postmenopausal osteoporosis, and the traditional Chinese herb pair Bunge/C.K. Schneid (AA/PC) may help treat it, though its mechanisms are not well understood.
  • Researchers used various methods, including serum pharmacochemistry and a mouse model, to investigate how AA/PC affects osteoporosis and its related mechanisms.
  • Results showed that AA/PC improved bone density better than either herb alone and regulated important biological pathways related to ferroptosis, suggesting that it could be an effective treatment for postmenopausal osteoporosis.
View Article and Find Full Text PDF
Article Synopsis
  • The study introduces a new method for 3D surface imaging that combines synthetic wavelength phase-based ranging and line-scan off-axis holography.
  • The system uses a faster tunable laser for quick wavelength switching and a galvanometer mirror for mechanical scanning, allowing for precise depth measurements.
  • Results show the system achieves micron-level depth accuracy over a field of view of 12.8 mm × 34 mm with a rapid image acquisition time of just 50 ms.
View Article and Find Full Text PDF

Want AI Summaries of new PubMed Abstracts delivered to your In-box?

Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!