AI Article Synopsis
- Scientists are testing different types of stem cells to see if they can help heal hearts after a heart attack.
- There is no clear winner among the stem cell types, as they all seem to help in similar ways.
- The good effects from these cells likely come from their ability to send helpful signals to the heart rather than fixing it directly.
Article Abstract
Injection of various stem cells has been tested with the hopes of improving cardiac function after a myocardial infarction (MI). However, there is continued controversy as to which cell type is best for repair. Due to technical differences in cell isolation, processing, delivery, and cardiac functional assessment by various investigators, it has been difficult to directly compare the results of different cells. Using same techniques to evaluate the efficacy of different cell types, we have separately delivered bone marrow cells (BMCs), cardiospheres (CSs), CS-derived Sca-1(+)/CD45(-) cells, human embryonic stem cell-derived cardiomyocytes, and BMC extract into infarcted murine myocardium and found that all of these treatments reduce infarct size and improve cardiac function post-MI similarly without one regimen being superior to another. The beneficial effects appear to be via paracrine influences. Different progenitors lead to improved cardiac function post-MI, but it is premature to hype any specific cell type at this time.
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| http://dx.doi.org/10.1007/s10741-015-9494-7 | DOI Listing |
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