Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4420299 | PMC |
Publication Analysis
Top Keywords
Similar Publications
MicroRNA regulation of enteric nervous system development and disease.
Trends Neurosci
March 2025
Biomedical Research Institute (BIOMED), Hasselt University, Diepenbeek, Belgium; Department of Pathology, GROW - Research Institute for Oncology and Reproduction, Maastricht University Medical Center, Maastricht, The Netherlands. Electronic address:
The enteric nervous system (ENS), an elaborate network of neurons and glia woven through the gastrointestinal tract, is integral for digestive physiology and broader human health. Commensurate with its importance, ENS dysfunction is linked to a range of debilitating gastrointestinal disorders. MicroRNAs (miRNAs), with their pleiotropic roles in post-transcriptional gene regulation, serve as key developmental effectors within the ENS.
View Article and Find Full Text PDFSurgical long-term outcomes of Hirschsprung Disease in the Democratic Republic of Congo: a case series of 31 patients in a resource-limited setting.
BMC Surg
March 2025
Faculty of Medicine, Catholic University of Bukavu, Bukavu, South Kivu, Democratic Republic of Congo.
Background: Hirschsprung disease (HD) contributes significantly to the burden of disease related to conditions amenable to pediatric surgery within the Democratic Republic of Congo (DRC). However, it has received less clinical attention due to limited resources. We aimed at assessing the long-term follow-up outcomes following an innovate resection approach in South Kivu, eastern DRC.
View Article and Find Full Text PDFDiagnosis and Prevention of Transition Zone Pull-through in Patients With Hirschsprung Disease.
Arch Pathol Lab Med
March 2025
From the Departments of Laboratory Medicine and Pathology (Kapur) and Pediatric Surgery (Smith), Seattle Children's Hospital and University of Washington, Seattle.
Context.—: Surgery for Hirschsprung disease includes resection of the aganglionic bowel and adjacent transition zone (ganglionic bowel with partial circumferential aganglionosis, myenteric hypoganglionosis, and/or submucosal nerve hypertrophy). Pathology practices, including intraoperative frozen sections and sampling of resection specimens and accurate recognition and reporting of transition zone histopathology, are necessary to both prevent and diagnose incomplete resection.
View Article and Find Full Text PDFMowat-Wilson Syndrome in Hirschsprung: Something Special or Just a Generic Problem?
J Pediatr Surg
March 2025
Department of Surgery, ANU Medical School, The Canberra Hospital, Garran ACT 2605, Australia. Electronic address:
The author comments on the recent paper by Cheng et al describing a series of MWS patients derived from a much larger series of HSCR patients. Children operated for HSCR with developmental delay suffer more difficulties than children without, but the literature varies on the outcomes associated with developmental delay such as Down syndrome and MWS. The author suggests that the degree of developmental delay has a bearing on outcome, and he further asks whether MWS has any particular features to make its prognosis different from other developmental delay syndromes associated with HSCR.
View Article and Find Full Text PDFPlasma NMDAR autoantibody: a new biomarker for the diagnosis of Hirschsprung disease.
Front Pediatr
February 2025
Guangdong Provincial Key Laboratory of Research in Structural Birth Defect Disease, Department of Pediatric Surgery, Guangzhou Women and Children's Medical Center, Guangdong Provincial Clinical Research Center for Child Health, Guangzhou Medical University, Guangzhou, Guangdong, China.
Introduction: Hirschsprung Disease (HSCR) is a common congenital intestinal disease in pediatrics. Early diagnosis and treatment after birth alleviate the occurrence of complications. Consequently, we aim to identifiy a biomarker with ease of use, non-invasiveness, and highly accurate for diagnosis.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!