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Gut healing: haemocytes aid via Sax and Tkv jazzes it down. | LitMetric

Gut healing: haemocytes aid via Sax and Tkv jazzes it down.

Nat Cell Biol

1] Department of Biochemistry and Molecular Biology and the Division of Reproductive Biology, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, Maryland, 21205, USA [2] Department of Environmental Health Sciences, Johns Hopkins University, Baltimore, Maryland, 21205, USA.

Published: June 2015

Control of stem cell activity is essential for accurate regeneration. Pathogen- or chemical-induced intestinal damage is now shown to recruit haemocytes expressing bone morphogenetic protein signals that stimulate proliferation of intestinal stem cells and subsequently induce their quiescence, in conjunction with muscle-derived bone morphogenetic proteins. A temporal switch in expression of Type I receptors enables this two-phase response.

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Source
http://dx.doi.org/10.1038/ncb3178DOI Listing

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