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Vesalius and His Manikin: An Enduring Influence on Modern Anatomic Teaching.
Neurosurgery
February 2025
The Loyal and Edith Davis Neurosurgical Research Laboratory, Department of Neurosurgery, Barrow Neurological Institute, St. Joseph's Hospital and Medical Center, Phoenix , Arizona , USA.
Anatomic teaching has long informed surgical knowledge, experience, and skills. One tool for teaching that emerged during the Renaissance was the fugitive anatomic sheet, which used flap layers to reveal different levels of anatomy. In 1538, Vogtherr introduced the first fugitive sheets, which included illustrations of male and female figures with a torso paper flap that, when lifted, revealed the internal organs in a cartoonish style.
View Article and Find Full Text PDFHow does news affect biopharma stock prices?: An event study.
PLoS One
February 2024
Laboratory for Financial Engineering, MIT, Cambridge, MA, United States of America.
We investigate the impact of information on biopharmaceutical stock prices via an event study encompassing 503,107 news releases from 1,012 companies. We distinguish between pharmaceutical and biotechnology companies, and apply three asset pricing models to estimate their abnormal returns. Acquisition-related news yields the highest positive return, while drug-development setbacks trigger significant negative returns.
View Article and Find Full Text PDFRationale and design of the effect of evolocumab in patients at high cardiovascular risk without prior myocardial infarction or stroke (VESALIUS-CV) trial.
Am Heart J
March 2024
TIMI Study Group, Cardiovascular Division, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA.
Article Synopsis
- Evolocumab, a PCSK9 inhibitor, has been shown to lower LDL-C and reduce cardiovascular risks in patients with existing heart conditions, but its effects on lower-risk patients are still unclear.
- The VESALIUS-CV trial is testing whether evolocumab can prevent major cardiovascular events in high-risk patients without prior heart issues, involving over 12,000 participants.
- The study aims to evaluate the drug's effectiveness on specific cardiovascular outcomes over a median follow-up of 4.5 years, with recruitment completed by November 2021.
Deep profiling of multiple ischemic lesions in a large, multi-center cohort: Frequency, spatial distribution, and associations to clinical characteristics.
Front Neurosci
August 2022
Department of Clinical Sciences Lund, Radiology, Lund University, Lund, Sweden.
Background Purpose: A substantial number of patients with acute ischemic stroke (AIS) experience multiple acute lesions (MAL). We here aimed to scrutinize MAL in a large radiologically deep-phenotyped cohort.
Materials And Methods: Analyses relied upon imaging and clinical data from the international MRI-GENIE study.
[A Novel Virtual-reality Imaging System in Cardiovascular Surgery:a Potentially Promising Technology for Surgeons].
Kyobu Geka
June 2022
Department of Cardiovascular Surgery, Shiga University of Medical Science, Otsu, Japan.
Adequate preoperative planning may facilitate successful procedures in cardiovascular surgery. We have developed a system named the Vesalius 3D suite, combining three-dimensional (3D) image-processing software with an optic-tracking spatial navigation, allowing quick, accessible 3D image interpretation for virtual reality (VR) exploration and measurement from one or more of a range of imaging modalities. We present a novel method of virtual imaging analysis for preoperative planning and simulation in cardiovascular surgery using this 3D-VR system.
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