AI Article Synopsis
- A 34-week infant with neonatal abstinence syndrome (NAS) developed complications shortly after birth, including acute kidney injury and hydronephrosis, following maternal drug use.
- Positive urine tests indicated exposure to cocaine and heroin, and the infant was treated with oral morphine for NAS symptoms.
- The resolution of the renal issues after stopping morphine and catheterizing suggests that the infant's genetic makeup may have contributed to morphine accumulation, leading to kidney toxicity.
Article Abstract
A 34-week infant born from a mother with a history of drug abuse developed neonatal abstinence syndrome (NAS) in the first hours of life. Urine drug screening was positive for cocaine and heroin. The infant developed acute kidney injury and bilateral hydronephrosis while receiving oral morphine for control of NAS. Cessation of morphine therapy and urinary catheterization resulted in a rapid and complete resolution of the symptoms. Our patient was homozygous for the C3435T polymorphism in the ABCB1 gene, a polymorphism previously associated with impaired P-glycoprotein activity. We hypothesize that acute renal toxicity was related to accumulation of morphine within urothelial cells due to genetically determined impaired P-glycoprotein activity.
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Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4432415 | PMC |
| http://dx.doi.org/10.1093/ckj/sfs099 | DOI Listing |
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