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Heart rate variability impairment during sleep in Veterans with rapid eye movement sleep behaviour disorder, traumatic brain injury, and post-traumatic stress disorder: an early potential window into autonomic dysfunction?
J Sleep Res
March 2025
VA Portland Health Care System, Research Service, Portland, Oregon, USA.
Individuals with comorbid rapid eye movement (REM) sleep behaviour disorder (RBD) and neurotrauma (NT; defined by traumatic brain injury and post-traumatic stress disorder) have an earlier age of RBD symptom onset, increased RBD-related symptom severity and more neurological features indicative of prodromal synucleinopathy compared to RBD only. An early sign of neurodegenerative condition is autonomic dysfunction, which we sought to evaluate by examining heart rate variability during sleep. Participants with overnight polysomnography were recruited from the Veterans Affairs Portland Health Care System.
View Article and Find Full Text PDFImported loiasis: Diagnostic and therapeutic challenges.
Infect Dis Now
March 2025
Parasitology Laboratory, Bichat-Claude Bernard Hospital, AP-HP Nord and Université Paris Cité, 46, Rue Henri Huchard 75018 Paris, France; IRD MERIT UMR 261, Pharmacy Faculty, Université Paris Cité, 4, Avenue de l'observatoire, 75006 Paris, France.
Loiasis is a vector-borne parasitic disease that has long been neglected due to its benign nature and its geographical distribution, which is restricted to the forest regions of Central and West Africa. However, it is now recognized as a significant public health concern in endemic areas, where chronically infected patients face organ damage and an increased risk of mortality. Loiasis presents several challenges, from diagnosis to treatment, as inappropriate therapies can lead to severe and at times fatal side effects.
View Article and Find Full Text PDFPer- and polyfluoroalkyl substances and type 2 diabetes among older adults: Synthesizing cross-sectional population study and meta-analysis.
Int J Hyg Environ Health
March 2025
State Key Laboratory of Environment Health (Incubation), Key Laboratory of Environment and Health, Ministry of Education, Key Laboratory of Environment and Health (Wuhan), Ministry of Environmental Protection, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, #13 Hangkong Road, Wuhan, Hubei, 430030, China. Electronic address:
The effects of per- and polyfluoroalkyl substances (PFASs) on type 2 diabetes (T2D) remain unclear. We aimed to explore the effects of PFASs exposure on glucose metabolism disorders in older adults. We enrolled 704 elderly individuals aged over 65 years from Wuhan, China.
View Article and Find Full Text PDFPhysiological monitoring for occupational heat stress management: recent advancements and remaining challenges.
Appl Physiol Nutr Metab
March 2025
University of Ottawa, Human and Environmental Physiology Research Unit, School of Human Kinetics, Ottawa, Ontario, Canada;
Occupational heat stress poses a major threat to worker health and safety that is projected to worsen with global climate warming. To manage these adverse effects, most industries rely on administrative controls (stay times and work-to-rest allocations) that are designed to limit the rise in body core temperature in the 'average' individual. However, due to the extensive inter- and intra-individual variation in thermoregulatory function, these administrative controls will result in some individuals having their work rate and productivity unnecessarily restricted (false positives), while others may be subject to rises in heat strain that compromise health (false negatives).
View Article and Find Full Text PDFPathway-Dependent Control of Chiral Phases for Higher Performance and Inverted Circularly Polarized Luminescence.
Angew Chem Int Ed Engl
March 2025
Shenzhen University, College of Chemistry and Environmental Engineering,, CHINA.
Chiral luminescent materials have garnered increasing attention for their exceptional ability to emit circularly polarized luminescence (CPL) along with their excellent applications. Here, a cyclohexylidene scaffold was conceptualized as a chiral source for developing higher performance CPL materials in term of simultaneously enhanced quantum yields (PLQYs) and dissymmetry factor. It was found that the axially chiral scaffold attached with a cyanostilbene showed a pathway dependent assembly route to form chiral luminescent liquid crystals and crystal upon fast and slow cooling, respectively.
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