AI Article Synopsis
- The study investigated the toxic effects of silver (AgNP) and titanium dioxide (TiO2) nanoparticles on human lymphocytes by analyzing gene expression related to inflammation and apoptosis.
- An increase in the expressions of IL-6, IL-8, TNF-α, and p53 genes was observed when exposed to these nanoparticles at concentrations of 10-40 μg/ml.
- The heightened expression of these genes suggests that the nanoparticles may stimulate the immune response and promote apoptosis in human cells.
Article Abstract
In order to evaluate the toxic effect of silver (AgNP) and titanium dioxide (TiO2) nanoparticles their influence on the expression of genes of biomarkers of inflammatory responses and apoptosis in human lymphocytes was studied. An increase in the IL-6, IL-8, TNF-α and p53 genes expression in the concentration range of silver and titanium dioxide nanoparticles of 10-40 μk g/ml was found. Increased expression of IL-6, IL-8, TNF-α and p53 genes under the nanoparticles action indicates the stimulation of the immune system and of apoptosis, respectively.
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