The touch dome is a highly patterned mechanosensory structure in the epidermis composed of specialized keratinocytes in juxtaposition with innervated Merkel cells. The touch dome epithelium is maintained by tissue-specific stem cells, but the signals that regulate the touch dome are not known. We identify touch dome stem cells that are unique among epidermal cells in their activated Hedgehog signaling and ability to maintain the touch dome as a distinct lineage compartment. Skin denervation reveals that renewal of touch dome stem cells requires a perineural microenvironment, and deleting Sonic hedgehog (Shh) in neurons or Smoothened in the epidermis demonstrates that Shh is an essential niche factor that maintains touch dome stem cells. Up-regulation of Hedgehog signaling results in neoplastic expansion of touch dome keratinocytes but no Merkel cell neoplasia. These findings demonstrate that nerve-derived Shh is a critical regulator of lineage-specific stem cells that maintain specialized sensory compartments in the epidermis.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4466733 | PMC |
| http://dx.doi.org/10.1073/pnas.1504177112 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Optical Micro/Nanofiber Enabled Multiaxial Force Sensor for Tactile Visualization and Human-Machine Interface.
Adv Sci (Weinh)
December 2024
State Key Laboratory of Extreme Photonics and Instrumentation, College of Optical Science and Engineering, Zhejiang University, Hangzhou, 310027, China.
Tactile sensors with capability of multiaxial force perception play a vital role in robotics and human-machine interfaces. Flexible optical waveguide sensors have been an emerging paradigm in tactile sensing due to their high sensitivity, fast response, and antielectromagnetic interference. Herein, a flexible multiaxial force sensor enabled by U-shaped optical micro/nanofibers (MNFs) is reported.
View Article and Find Full Text PDFBiomimetic Contact Behavior Inspired Tactile Sensing Array with Programmable Microdomes Pattern by Scalable and Consistent Fabrication.
Adv Sci (Weinh)
November 2024
Micro- and Nano-technology Research Center, State Key Laboratory for Manufacturing Systems Engineering, Xi'an Jiaotong University, Xi'an, Shaanxi, 710049, China.
Flexible sensor arrays have attracted extensive attention in human-computer interaction. However, realizing high-performance sensor units with programmable properties, and expanding them to multi-pixel flexible arrays to maintain high sensing consistency is still struggling. Inspired by the contact behavior of octopus antenna, this paper proposes a programmable multistage dome structure-based flexible sensing array with robust sensing stability and high array consistency.
View Article and Find Full Text PDFCementless, Cruciate-Retaining Primary Total Knee Arthroplasty Using Conventional Instrumentation: Technical Pearls and Intraoperative Considerations.
JBJS Essent Surg Tech
September 2024
Department of Orthopaedic Surgery, The Johns Hopkins Hospital, Baltimore, Maryland.
Article Synopsis
- Total knee arthroplasty (TKA) is a common surgical procedure for patients with severe knee osteoarthritis, especially when non-surgical treatments fail, leading to significant improvements in pain, function, and quality of life.
- The procedure can use various components (cemented, cementless, or a hybrid) and is generally performed with a focus on mechanical alignment, although newer alignment strategies like gap and kinematic balancing are showing promising results in early studies.
- The preferred surgical technique for cementless TKA involves a specific patient positioning and incision approach, starting with the application of a thigh tourniquet and a parapatellar incision, ensuring proper alignment and access during the surgery.*
Local Ablation Therapy for Hepatocellular Carcinoma: Clinical Significance of Tumor Size, Location, and Biology.
Invest Radiol
January 2025
From the Department of Radiology and Center for Imaging Science, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea (M.W.L., S.H., K.G., H.R.); and Department of Health Sciences and Technology, SAIHST, Sungkyunkwan University, Seoul, Republic of Korea (M.W.L., H.R.).
Local ablation therapy, encompassing radiofrequency ablation (RFA), microwave ablation, and cryoablation, has emerged as a crucial strategy for managing small hepatocellular carcinomas (HCCs), complementing liver resection and transplantation. This review delves into the clinical significance of tumor size, location, and biology in guiding treatment decisions for HCCs undergoing local ablation therapy, with a focus on tumors smaller than 3 cm. Tumor size significantly influences treatment outcomes, with larger tumors associated with poorer local tumor control due to challenges in creating sufficient ablative margins and the likelihood of microvascular invasion and peritumoral satellite nodules.
View Article and Find Full Text PDFFusion Testing in Patients With NSCLC: The RETING Study.
JTO Clin Res Rep
April 2024
Hospital Universitario 12 de Octubre, Madrid, Spain.
Article Synopsis
- * A study was conducted with 38 fusion-positive NSCLC samples, comparing NGS with FISH and RT-PCR, revealing that while NGS identified all cases, some fusions were missed by FISH and RT-PCR, highlighting limitations in these lesser methods.
- * The findings suggest that understanding the strengths and weaknesses of different testing techniques is crucial for improving clinical protocols, reinforcing the need for NGS as the primary approach to ensure accurate fusion detection
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!