This scientific commentary refers to ‘Direct visualization of alpha-synuclein oligomers reveals previously undetected pathology in Parkinson’s disease brain’, by Roberts (doi: 10.1093/brain/awv040).
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http://dx.doi.org/10.1093/brain/awv099 | DOI Listing |
BMC Geriatr
January 2025
School of Medicine, Qom University of Medical Sciences, Qom, Iran.
Introduction: Intrinsic Capacity in integrated geriatric care emphasizes the importance of a thorough functional assessment. Monitoring the intrinsic capacity of older individuals provides standardized and reliable information to prevent early disability. This study assessed the relationship between intrinsic capacity and functional ability in older adults.
View Article and Find Full Text PDFAutoimmun Rev
January 2025
Department of Orthopedics, Rheumatology and Traumatology-School of Medical Sciences, University of Campinas, Brazil; Autoimmunity Lab, School of Medical Sciences, University of Campinas, Brazil. Electronic address:
Introduction: Autoimmune diseases often present in a systemic manner, affecting various organs and tissues. Involvement of the central and peripheral nervous system is not uncommon in these conditions and is associated with high morbidity and mortality. Therefore, early recognition of the neuropsychiatric manifestations associated with rheumatologic diseases is essential for the introduction of appropriate therapies with the objective of providing a better quality of life for individuals.
View Article and Find Full Text PDFJ Endovasc Ther
January 2025
Department of Vascular Surgery, Swiss Aortic Center Bern, Inselspital, University Hospital of Bern, University of Bern, Bern, Switzerland.
Purpose: To perform a systematic review and meta-analysis of the outcomes of Anaconda fenestrated endograft for the treatment of complex abdominal aortic aneurysms (cAAA).
Material And Methods: A systematic search of all the literature reported until May 2024 was performed according to the PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analyses) guidelines. The pooled 30-day mortality rate, technical success rate, reintervention rate as well as bridging stent occlusion rate, and corresponding 95% confidence intervals (CIs) were estimated using fixed or random effect methods.
Pathogens
December 2024
State Research Center of Virology and Biotechnology "Vector", Koltsovo 630559, Russia.
Human Immunodeficiency Virus (HIV) proviral reservoirs are cells that harbor integrated HIV proviral DNA within their nuclear genomes. These cells form a heterogeneous group, represented by peripheral blood mononuclear cells (PBMCs), tissue-resident lymphoid and monocytic cells, and glial cells of the central nervous system. The importance of studying the properties of proviral reservoirs is connected with the inaccessibility of integrated HIV proviral DNA for modern anti-retroviral therapies (ARTs) that block virus reproduction.
View Article and Find Full Text PDFSensors (Basel)
January 2025
Industrial Systems Institute (ISI), Athena Research and Innovation Center, 26504 Patras, Greece.
The integration of deep learning (DL) into image processing has driven transformative advancements, enabling capabilities far beyond the reach of traditional methodologies. This survey offers an in-depth exploration of the DL approaches that have redefined image processing, tracing their evolution from early innovations to the latest state-of-the-art developments. It also analyzes the progression of architectural designs and learning paradigms that have significantly enhanced the ability to process and interpret complex visual data.
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