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Psychedelic-assisted treatment for substance use disorder: A narrative systematic review.
Addiction
January 2025
Addictions Department, School of Academic Psychiatry, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK.
Background And Aims: This is the first systematic review of the extant literature on all major psychedelic-assisted treatment for alcohol use disorder (AUD), tobacco use disorder (TUD) and other substance use disorders (SUD). We aimed to summarise the evidence for efficacy of psychedelic-assisted treatment for AUD, TUD, and SUD; to evaluate its quality; and to offer recommendations for research.
Methods: This was a prospectively registered narrative systematic review of open-label, randomised controlled trials (RCT), and observational studies of d-lysergic acid diethylamide (LSD), mescaline, psilocybin, ayahuasca, ketamine, ibogaine and 3,4-methylenedioxymethamphetamine (MDMA).
Association Between GABRG2 and Self-Rating of the Effects of Alcohol in a French Young Adult Sample.
Risk Manag Healthc Policy
January 2025
Université Paris Cité, Inserm U1266, Institut de Psychiatrie et Neurosciences de Paris (IPNP), Team Vulnerability of Psychiatric and Addictive Disorders, Paris, France.
Purpose: Alcohol use is a leading risk factor for preventable death, injury, and disease globally. Low sensitivity to the effects of alcohol is influenced by genes and predicts risk for harmful alcohol use and alcohol use disorder (AUD). Alcohol induces effects partly by modulation of gamma-aminobutyric acid receptors type A (GABARs).
View Article and Find Full Text PDFSystemic bupropion treatment reduces long-access cocaine self-administration in male and female rats.
J Psychopharmacol
January 2025
Department of Physiology, Louisiana State University Health Sciences Center, New Orleans, LA, USA.
Background: More than 1 million people in the United States meet the criteria for cocaine use disorder (CUD), and over 19,000 people died from cocaine-related overdoses in 2020, but there are currently no FDA-approved medications for the treatment of CUD. Bupropion is an antidepressant currently prescribed to treat depression and nicotine addiction that acts by inhibiting norepinephrine and dopamine transporters.
Methods: In this study, we tested the effect of several doses of systemic bupropion on cocaine self-administration in male and female Wistar rats.
BENEFICIAL AND HARMFUL TOBACCO USE TRANSITIONS ASSOCIATED WITH ENDS IN THE US.
Am J Prev Med
January 2025
Institute for Global Tobacco Control, Department of Health, Behavior and Society, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, United States.
Introduction: Electronic nicotine delivery systems (ENDS) can benefit those who use combustible tobacco if they transition completely to ENDS. ENDS can also result in nicotine addiction among nicotine naïve people.
Methods: ENDS-related tobacco use transitions were assessed among US youth and adults using weighted Population Assessment of Tobacco and Health Study wave four (2016-2017) and five (2018-2019) adult and youth data.
The Promotion of Oral Nicotine Pouches for Non-Smoking Cessation Purposes on TikTok.
Nicotine Tob Res
January 2025
Faculty of Public Health & Policy, London School of Hygiene and Tropical Medicine, Keppel St, London WC1E 7HT, United Kingdom.
Article Synopsis
- This study examines the most popular TikTok videos related to ZYN oral nicotine pouches, highlighting their positive sentiment and the demographics of the creators who often portray the product humorously.
- Out of the top 100 videos analyzed, which collectively amassed over 400 million views, a significant majority (79%) presented ZYN in a favorable light, with 71% of the videos featuring the product directly.
- Only a small number of videos included disclaimers about nicotine risks, and nearly 10% of content creators had links to websites selling ONPs, indicating a commercial bias in the promotion of these products.
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