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A New Method for Sham-Controlled Acupuncture in Experimental Visceral Pain - a Randomized, Single-Blinded Study. | LitMetric

AI Article Synopsis

  • This study aimed to develop a new method for sham acupuncture to effectively measure its impact on visceral pain, specifically rectal pain, in a controlled setting.
  • Fifteen participants were randomly assigned to receive either sham or real acupuncture, and their pain threshold was assessed through rectal stimulation with an inflatable balloon.
  • Results showed no significant differences in pain reduction or EEG activity between sham and real acupuncture, suggesting the sham method is effective for blinding and can be utilized in future research on acupuncture for visceral pain.

Article Abstract

Objective: Acupuncture is increasingly used as an alternative to medical therapy for various pain conditions. To study the effect of acupuncture in experimental and clinical studies, a control condition with sham acupuncture is needed. However, as such models have not been established in assessment of acupunctures effect against visceral pain, this study aimed to validate a new method for blinded sham acupuncture in experimental rectal pain.

Methods: Fifteen subjects underwent a sequence of either sham or real acupuncture in randomized order. In the sham arm, a hollow inner tube with a sharp tip was fitted into an outer tube and subjects were blinded to the stimulations. Before and after the intervention, pain was induced by rectal stimulation with an inflatable balloon distended until the subjects' pain threshold was reached. The resting electroencephalogram (EEG) was quantified by spectral power analysis to explore the central nervous system effects objectively. Additionally, after the second study day, the subject was asked to indicate the sequence of interventions.

Results: A significant increase in rectal balloon volume was observed after sham 12 ± 21 mL (P = 0.049) and acupuncture 17 ± 30 mL (P = 0.046). However, the change in volume was not different between groups (P = 0.6). No differences in EEG spectral power distributions between sham and acupuncture were seen (all P > 0.6). The correct sequence of sham and acupuncture was indicated by 36% of the subjects (P = 0.4).

Conclusions: The presented sham procedure provides a valid method for blinding of "sham acupuncture" and may be used in future blinded controlled trials of acupuncture for visceral pain.

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Source
http://dx.doi.org/10.1111/papr.12309DOI Listing

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