AI Article Synopsis
- The study investigated cases of mycosis fungoides (MF) that displayed epidermal mucinosis resembling spongiotic dermatitis, which is uncommon in MF.
- The researchers analyzed 30 skin biopsies from patients diagnosed with MF, confirming the presence of epidermal mucinosis and observing significant loss of specific T-cell antigens.
- The findings provide useful histopathologic criteria to differentiate MF with mucinosis from other similar skin conditions, potentially improving diagnosis.
Article Abstract
Background: The histopathologic diagnosis of mycosis fungoides (MF) has classically relied on the presence of atypical epidermotropic T-lymphocytes predominating over spongiosis. However, in some cases of MF, prominent epidermal mucinosis in a spongiosis-like pattern mimics a spongiotic dermatitis. To our knowledge, only one series in the literature has thus far recognized the presence of epidermal mucinosis in MF.
Methods: We evaluated 30 skin biopsies from 18 patients with the clinical diagnosis of MF, which fulfilled all histopathologic criteria for patch- or plaque-stage MF, but also showed epidermal mucinosis in a spongiosis-like pattern. A total of 15 specimens were studied by immunohistochemistry, and seven were tested for T-cell receptor (TCR) gene rearrangements. Twenty biopsies of spongiotic dermatitides were included as controls.
Results: We confirmed the presence of epidermal mucinosis in all 30 cases of MF with a spongiosis-like pattern based on histopathologic criteria and the colloidal iron stain for mucin. Immunohistochemistry in 15 specimens showed significant loss of pan-T-cell antigens CD5 (10/15) and CD7 (14/15); and TCR clonality was detected in 7 specimens from 6 patients, supporting the diagnosis of MF.
Conclusions: We report helpful histopathologic criteria for distinguishing MF with epidermal mucinosis in a spongiosis-like pattern from spongiotic dermatitis.
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| http://dx.doi.org/10.1111/cup.12513 | DOI Listing |
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