AI Article Synopsis
- Researchers studied the impact of Simkania negevensis infection on lung transplant rejection by analyzing 78 lung transplant recipients over a period from 2007 to 2010.
- The infection was detected using quantitative PCR techniques, and the relationship between the infection and acute cellular rejection (ACR) was assessed through various statistical models.
- Results indicated a higher cumulative incidence of ACR in patients positive for S. negevensis compared to those who were negative, suggesting a potential link, although it was not statistically significant.
Article Abstract
Simkania negevensis infection has been hypothesized to play a role in lung transplant rejection. The incidence of S. negevensis infection and its association with acute cellular rejection (ACR) were determined in a prospective cohort study of 78 lung transplant recipients (LTRs) in Toronto, Canada, and Pittsburgh, USA, from July 2007 to January 2010. Simkania negevensis testing was detected by quantitative polymerase chain reaction (PCR) on bronchoalveolar lavage fluid. The relationship between S. negevensis and ACR was examined using Cox proportional hazards models and generalized linear and latent mixed models. Cumulative incidence estimates for time-to-ACR in S. negevensis PCR-positive vs. PCR-negative LTRs were 52.7% vs. 31.1% at six months and 68.9% vs. 44.6% at one yr, respectively. Although not statistically significant, there was a trend toward a higher risk of ACR among S. negevensis PCR-positive vs. PCR-negative LTRs in all statistical models.
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| http://dx.doi.org/10.1111/ctr.12571 | DOI Listing |
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