The ryanodine receptor/Ca2+ release channel plays a pivotal role in skeletal and cardiac muscle excitation-contraction coupling. Defective regulation leads to neuromuscular disorders and arrhythmogenic cardiac disease. This mini-review focuses on channel regulation through structural intra- and inter-subunit interactions and their implications in ryanodine receptor pathophysiology.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1042/BST20140292 | DOI Listing |
Publication Analysis
Top Keywords
ryanodine receptor
8
structural functional
4
functional interactions
4
interactions ryanodine
4
receptor ryanodine
4
ryanodine receptor/ca2+
4
receptor/ca2+ release
4
release channel
4
channel plays
4
plays pivotal
4
Similar Publications
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!