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DNA methylation-based predictors of metabolic traits in Scottish and Singaporean cohorts.
Am J Hum Genet
January 2025
Centre for Genomic and Experimental Medicine, Institute of Genetics and Cancer, University of Edinburgh, Edinburgh, UK.
Exploring the molecular correlates of metabolic health measures may identify their shared and unique biological processes and pathways. Molecular proxies of these traits may also provide a more objective approach to their measurement. Here, DNA methylation (DNAm) data were used in epigenome-wide association studies (EWASs) and for training epigenetic scores (EpiScores) of six metabolic traits: body mass index (BMI), body fat percentage, waist-hip ratio, and blood-based measures of glucose, high-density lipoprotein cholesterol, and total cholesterol in >17,000 volunteers from the Generation Scotland (GS) cohort.
View Article and Find Full Text PDFCuration and validation of electronic medical record-based dementia diagnoses in the VA Million Veteran Program.
J Alzheimers Dis
December 2024
National Center for PTSD, Behavioral Sciences Division, VA Boston Healthcare System, Boston, USA.
Background: The age distribution and diversity of the VA Million Veteran Program (MVP) cohort make it a valuable resource for studying the genetics of Alzheimer's disease (AD) and related dementias (ADRD).
Objective: We present and evaluate the performance of several International Classification of Diseases (ICD) code-based classification algorithms for AD, ADRD, and dementia for use in MVP genetic studies and other studies using VA electronic medical record (EMR) data. These were benchmarked relative to existing ICD algorithms and AD-medication-identified cases.
Disturbing sleep in female adolescent mice does not increase vulnerability to depression triggers later in life.
Brain Behav Immun
December 2024
Department of Neuroscience, University of Copenhagen, Blegdamsvej 3B, 2200 Copenhagen, Building 24-6, Denmark. Electronic address:
Poor sleep quality is a major issue for many adolescents and is associated with fatigue, poor academic performance, and depression. Adolescence is a crucial neurodevelopmental stage where multiple neuropsychiatric illnesses often emerge, suggesting increased central nervous system vulnerability, specifically at this age, which could be exacerbated by poor sleep. Studies on adolescent mice show that sleep deprivation or sleep disturbance (SD) induces structural and functional brain changes, indicating that SD affects the adolescent brain.
View Article and Find Full Text PDFSpace scan statistics to identify clusters of neonatal mortality associated with bacterial sepsis.
Epidemiol Infect
December 2024
Escola Paulista de Medicina, Universidade Federal de São Paulo, São Paulo, Brazil.
Our study aim was to identify high-risk areas of neonatal mortality associated with bacterial sepsis in the state of São Paulo, Southeast Brazil. We used a population-based study applying retrospective spatial scan statistics with data extracted from birth certificates linked to death certificates. All live births from mothers residing in São Paulo State from 2004 to 2020 were included.
View Article and Find Full Text PDFSex-stratified Genomic Structural Equation Models of Posttraumatic Stress Inform PTSD Etiology: L'utilisation de la modélisation génomique par équations structurelles stratifiée par sexe du stress post-traumatique pour expliquer l'étiologie du TSPT.
Can J Psychiatry
December 2024
Department of Anthropology, University of Toronto, Toronto, ON, Canada.
Article Synopsis
- PTSD affects a notable percentage of the global population, with significant sex differences influencing its symptoms, yet the genetic factors behind these differences had been underexplored.
- A study conducted a multivariate genome-wide association study (GWAS) on UK Biobank individuals, revealing distinct symptom patterns for males and females and identifying specific significant genetic loci in females but not in males.
- The findings highlight the importance of considering sex when studying PTSD, suggesting that genetic factors may contribute to differing symptomatology and warrants further investigation into this area.
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