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Transcriptome-based network analysis of cell cycle-related genes in response to blue and red light in maize.
AoB Plants
December 2023
Northeast Institute of Geography and Agroecology, Chinese Academy of Sciences, No. 4888, Shengbei Street, Gaoxin North District, Changchun 130000, Jilin, China.
In maize, blue and red light are key environmental factors regulating cell-cycle progression. We used transcriptomics to investigate and compare differential gene expression under the four light conditions: red light, blue light, red converted to blue and blue converted to red. A total of 23 differentially expressed genes were identified.
View Article and Find Full Text PDFProtective Effect of Dexmedetomidine against Hyperoxia-Damaged Cerebellar Neurodevelopment in the Juvenile Rat.
Antioxidants (Basel)
April 2023
Department of Neonatology, Charité-Universitätsmedizin Berlin, Augustenburger Platz 1, 13353 Berlin, Germany.
Impaired cerebellar development of premature infants and the associated impairment of cerebellar functions in cognitive development could be crucial factors for neurodevelopmental disorders. Anesthetic- and hyperoxia-induced neurotoxicity of the immature brain can lead to learning and behavioral disorders. Dexmedetomidine (DEX), which is associated with neuroprotective properties, is increasingly being studied for off-label use in the NICU.
View Article and Find Full Text PDFImpaired migratory phenotype of CD4 T cells in Parkinson's disease.
NPJ Parkinsons Dis
December 2022
Department of Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden.
Dysfunctions in the immune system appear implicated in both disease onset and progression of Parkinson's disease (PD). Neurodegeneration observed in the brain of PD patients has been associated with neuroinflammation that is linked to alterations in peripheral adaptive immunity, where CD4 T cells are key players. In the present study, we elucidated the immunological aspect of PD by employing a wide range of cellular assays, immunocytochemistry and flow cytometry to examine CD4 T cells.
View Article and Find Full Text PDFMeta-analysis of epigenome-wide association studies in newborns and children show widespread sex differences in blood DNA methylation.
Mutat Res Rev Mutat Res
June 2022
Children's Environmental Health Laboratory, Division of Environmental Health Sciences, School of Public Health, University of California, Berkeley, CA, USA.
Article Synopsis
- Research shows that children exhibit sex-specific differences in disease prevalence, onset age, and susceptibility, potentially linked to DNA methylation variations.
- A meta-analysis of 8438 newborns and 4268 older children found significant differences in DNA methylation at nearly 47,000 CpG sites, with males generally showing lower methylation than females.
- The study identified additional methylation sites related to conditions like cancer and psychiatric disorders, emphasizing the role of DNA methylation in understanding health disparities between sexes.
Inflammation and Brain Structure in Schizophrenia and Other Neuropsychiatric Disorders: A Mendelian Randomization Study.
JAMA Psychiatry
May 2022
Institute for Mental Health, University of Birmingham, Birmingham, United Kingdom.
Importance: Previous in vitro and postmortem research suggests that inflammation may lead to structural brain changes via activation of microglia and/or astrocytic dysfunction in a range of neuropsychiatric disorders.
Objective: To investigate the relationship between inflammation and changes in brain structures in vivo and to explore a transcriptome-driven functional basis with relevance to mental illness.
Design, Setting, And Participants: This study used multistage linked analyses, including mendelian randomization (MR), gene expression correlation, and connectivity analyses.
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