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Ethanol abolishes ventilatory long-term facilitation and blunts the ventilatory response to hypoxia in female rats.
Respir Physiol Neurobiol
January 2025
Department of Neuroscience, Spinal Cord and Brain Injury Research Center, College of Medicine, University of Kentucky, 741 S. Limestone St., Lexington, KY 40508, USA.. Electronic address:
Obstructive sleep apnea (OSA) is a breathing disorder in which airway obstruction during sleep leads to periodic bouts of inadequate (hypopneic) or absent (apneic) ventilation despite neurorespiratory effort. Repetitive apneic and hypopneic exposures can induce intermittent hypoxemia and lead to a host of maladaptive behavioral and physiological outcomes. Intermittent hypoxia treatment (IH), which consists of alternating exposure to hypoxic and normal air, can induce a long-lasting increase in breathing motor outputs called long term facilitation (LTF).
View Article and Find Full Text PDFAcute intermittent hypoxia elicits sympathetic neuroplasticity independent of peripheral chemoreflex activation and spinal cord tissue hypoxia in a rodent model of high-thoracic spinal cord injury.
Exp Neurol
February 2025
International Collaboration on Repair Discoveries, University of British Columbia, Vancouver, BC, Canada; Centre for Chronic Disease Prevention and Management, University of British Columbia, Kelowna, BC, Canada; Department of Cellular and Physiological Sciences, Faculty of Medicine, University of British Columbia, Vancouver, BC, Canada. Electronic address:
Article Synopsis
- The study investigates how spinal cord injury (SCI) impacts the body's ability to control heart and blood vessels, leading to cardiovascular diseases (CVD) due to loss of medullary control.
- It explores acute intermittent hypoxia (AIH) as a potential treatment to stimulate sympathetic nerve activity and promote neuroplastic changes called long-term facilitation (LTF) in the sympathetic circuits after SCI.
- Results show that a single session of AIH can effectively boost sympathetic nerve activity in a rat model of SCI, opening possibilities for chronic AIH treatment to manage complications from sympathetic hypoactivity.
Effect of endothelin-1 on the blood pressure response to acute hypoxia and hyperoxia in healthy young men.
Physiol Rep
September 2024
Department of Nutrition and Exercise Physiology, University of Missouri, Columbia, Missouri, USA.
Endothelin-1 (ET-1) and its receptors are linked to increases in sensitivity of the chemoreceptors to hypoxic stress and the development of hypertension in preclinical models. We hypothesized ET receptor antagonism would lower resting blood pressure (BP) as well as the acute BP response to chemoreflex stress. Twenty-four men (31 ± 5 years, 26 ± 3 kg/m) completed two study visits (control, bosentan).
View Article and Find Full Text PDFChemoreflex sensitization occurs in both male and female rats during recovery from acute lung injury.
Front Physiol
July 2024
Department of Cellular and Integrative Physiology, University of Nebraska Medical Center, Omaha, NE, United States.
Introduction: Sex-specific patterns in respiratory conditions, such as asthma, COPD, cystic fibrosis, obstructive sleep apnea, and idiopathic pulmonary fibrosis, have been previously documented. Animal models of acute lung injury (ALI) have offered insights into sex differences, with male mice exhibiting distinct lung edema and vascular leakage compared to female mice. Our lab has provided evidence that the chemoreflex is sensitized in male rats during the recovery from bleomycin-induced ALI, but whether sex-based chemoreflex changes occur post-ALI is not known.
View Article and Find Full Text PDFGestational intermittent hypoxia reduces mandibular growth with decreased expression and increased expression in male offspring rats.
Front Physiol
June 2024
Department of Orthodontic Science, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University (TMDU), Tokyo, Japan.
Introduction: Maternal obstructive sleep apnea (OSA) during pregnancy is the risk factor for impaired fetal growth with low birth weight in the offspring. However, it is unclear whether gestational intermittent hypoxia (IH, a hallmark of maternal OSA) has long-term detrimental consequences on the skeletal development of offspring. This study aimed to investigate postnatal maxillofacial bone growth and cartilage metabolism in male and female offspring that were exposed to gestational IH.
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