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Olanzapine-Induced Black Hairy Tongue During Treatment of Hebephrenic Schizophrenia Decompensation: A Rare Case Report and Brief Review of the Literature.
Cureus
December 2024
Department of Psychiatry, Unidade Local de Saúde do Alto Ave, Guimarães, PRT.
Black hairy tongue (BHT) is a benign, self-limiting, and usually asymptomatic condition, characterized by abnormally hypertrophied and elongated filiform papillae on the surface of the tongue. In this article, we present the case of a woman diagnosed with hebephrenic schizophrenia who developed BHT after using olanzapine to treat an acute episode of the disease. The temporal coincidence between the development of BHT and the increase in olanzapine dosage to 20 mg daily suggests a likely dose-dependent relationship, making this psychotropic drug the most probable cause of this condition.
View Article and Find Full Text PDFA Rare Occurrence of Delayed Olanzapine-Induced Oculogyric Crisis in a Postpartum Patient: A Case Report.
Cureus
September 2024
Psychiatry, Al Amal Psychiatric Hospital, Emirates Health Services, Dubai, ARE.
Oculogyric crisis (OGC) is an acute dystonic reaction characterized by involuntary upward deviation of the eyes, often linked to the use of antipsychotic medications. While commonly associated with first-generation antipsychotics (FGAs) due to their higher propensity to cause extrapyramidal symptoms (EPS), OGC remains a rare but documented occurrence with second-generation antipsychotics (SGAs). SGAs, including olanzapine, are generally preferred in clinical practice due to their reduced risk of EPS; however, they are not completely devoid of such adverse effects.
View Article and Find Full Text PDFOlanzapine-Induced Acute Pulmonary Embolism.
Cureus
September 2024
Psychiatry, Faculty of Medicine and Pharmacy, Mohammed I University, Oujda, MAR.
Pulmonary embolism is defined as the abrupt obliteration of the trunk or a branch of the pulmonary artery by an embolus most often from a deep vein thrombosis of the lower limbs. It is serious, underdiagnosed, and can be life-threatening. We report the case of a patient who presented with a massive acute pulmonary embolism while taking olanzapine.
View Article and Find Full Text PDFA Possible Role of Akkermansia muciniphila in the Treatment of Olanzapine-Induced Weight Gain.
Cureus
March 2024
Department of Mental Health, Azienda Sanitaria Universitaria Giuliano Isontina, Trieste, ITA.
Second-generation antipsychotics are mainly used in both acute and long-term treatment of major psychiatric disorders. Although better tolerated than first-generation antipsychotic drugs, they can frequently induce weight gain and metabolic disorders, of these, olanzapine is one of the drugs more likely to induce these side effects. There is consistent evidence of the role of gut microbiota in modulating the gut-brain axis with complex crosstalk with the host involving satiety signaling pathways, food intake behavior, and weight and metabolic regulation.
View Article and Find Full Text PDFAmylin receptor agonism enhances the effects of liraglutide in protecting against the acute metabolic side effects of olanzapine.
iScience
January 2024
School of Kinesiology, University of British Columbia, Vancouver, BC V6T 1Z1, Canada.
Olanzapine is a second-generation antipsychotic (AP) used in the management of schizophrenia. Although effective at reducing psychoses, APs cause rapid hyperglycemia, insulin resistance, and dyslipidemia, an effect mediated in part by glucagon. We tested if amylin, a hormone that reduces glucagon, or the amylin receptor agonist pramlintide would protect against acute olanzapine-induced impairments in glucose and lipid homeostasis alone or in combination with other glucose-lowering agents such as liraglutide.
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