AI Article Synopsis
- Understanding the immune response to tuberculosis is crucial for developing effective vaccines but is currently limited.
- Genome-wide RNA analysis is a new method that helps researchers study the immune reactions to Mycobacterium tuberculosis (MTB).
- The study aims to use existing RNA expression data to identify immune responses that make individuals susceptible to TB, understand why some patients fail to mount an effective immune response, and pinpoint protective immune features in healthy individuals.
Article Abstract
A major limitation in the development and testing of new tuberculosis (TB) vaccines is the current inadequate understanding of the nature of the immune response required for protection against either infection with Mycobacterium tuberculosis (MTB) or progression to disease. Genome wide RNA expression analysis has provided a new tool with which to study the inflammatory and immunological response to mycobacteria. To explore how currently available transcriptomic data might be used to understand the basis of protective immunity to MTB, we analysed and reviewed published RNA expression studies to (1) identify a "susceptible" immune response in patients with acquired defects in the interferon gamma pathway; (2) identify the "failing" transcriptomic response in patients with TB as compared with latent TB infection (LTBI); and (3) identify elements of the "protective" response in healthy latently infected and healthy uninfected individuals.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4582769 | PMC |
| http://dx.doi.org/10.1016/j.vaccine.2015.05.025 | DOI Listing |
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