Background: Few studies have explored the association between renal function and major subtypes of mild cognitive impairment (MCI).
Methods: The sample was from the Einstein Aging Study. The estimated glomerular filtration rate (eGFR, calculated in mL/min/1.73m2 units) was classified into low (<45), moderate (45-59) and high (≥60). Separate binary logistic regression models were run to determine if eGFR is associated withamnestic MCI (aMCI) and dysexecutive MCI (dMCI).
Results: Out of 622 eligible participants 65 (10.5%) had low eGFR, 43 (7.1%) had aMCI, and 46 (7.6) had dMCI. Low eGFR was independently associated with dMCI and aMCI in fully adjusted models.
Conclusion: At cross-section low eGFR is associated with a higher risk of both dMCI and aMCI. eGFR may contribute to the development of these cognitive states directly. Alternatively, low eGFR may be a marker for risk factors that influence both the kidney and the brain, such as coronary microvascular disease.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4438786 | PMC |
| http://dx.doi.org/10.1016/j.dadm.2014.12.002 | DOI Listing |
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