AI Article Synopsis
- The study aimed to assess how well changes in metabolic syndrome (MS) and fasting plasma glucose (FPG) can predict the risk of developing Type 2 Diabetes (T2DM) over time.
- A cohort of 3,461 participants was followed for 3.8 years, using statistical methods to determine the predictive abilities of different indicators related to T2DM.
- The findings revealed that the change in FPG was the most effective predictor of T2DM, significantly outperforming baseline measurements of FPG and MS in identifying at-risk individuals.
Article Abstract
Background: The aim was to compare the predictive power for Type 2 Diabetes mellitus (T2DM) using dynamic change (Difference) of metabolic syndrome (MS), Difference of fasting plasma glucose (FPG), baseline MS and FPG in cohort study.
Methods: Overall, 3461 subjects were recruited from Prevention of Multiple Metabolic disorders and MS in Jiangsu of China Study with 3.8 years follow-up. Cox proportional-hazards regression and receiver operating characteristic were used to evaluate the predictive power for T2DM using Difference MS, Difference of FPG, baseline MS and FPG.
Results: Adjusted relative risk (aRR 5.24, 95% CI 4.28-6.42) of Difference of FPG to T2DM was highest than other. Difference of FPG owns the largest AUC (0.89, P<0.05), the highest sensitivity (96.25%) and specificity (80.49%) demonstrating that Difference of FPG can provide strongest predictive information to T2DM, Difference of MS comes second. Between FPG related tools, sensitivity of Difference of FPG almost was twice than baseline FPG(96.25% vs. 54.38%) suggesting that using baseline FPG would missed found 46% T2DM patients. Among MS related indicators, sensitivity of Difference of MS almost was twice than baseline MS (sensitivity 66.25% vs. 39.38%) suggesting that using baseline would missed found 61% T2DM patients.
Conclusion: Dynamic change of FPG had the highest predictive power for T2DM in Chinese than Dynamic Change of MS, baseline MS and FPG.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4433724 | PMC |
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