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Hereditary angioedema in children: Review and practical perspective for clinical management.
Pediatr Allergy Immunol
December 2024
French National Reference Center for Angioedema (CREAK), Center of Excellence and Reference (ACARE), Internal Medicine Department, Grenoble Alpes University Hospital, Grenoble, France.
Background: Hereditary angioedema (HAE) in children has specific features and requires multidisciplinary management.
Methods: We performed a literature search and underwent in-depth discussions to provide practical tools for physicians.
Results: HAE is a rare, life-threatening genetic disorder.
Article Synopsis
- - Systemic lupus erythematosus (SLE) can manifest in various ways, making it hard to diagnose; this case involved a 23-year-old woman who presented with severe swelling and respiratory issues, which were later identified as symptoms of SLE.
- - Initial treatment involved high-dose steroids and pulse therapy with methylprednisolone; however, the patient developed sepsis and an SLE flare due to an infection at the tracheostomy site.
- - After broad-spectrum antibiotics and a gradual reduction of steroids, along with maintenance therapy with azathioprine, the patient's condition improved, leading to the successful reversal of the tracheostomy and her discharge from the hospital.
A suspected anaphylactoid reaction to intravenous administration of mannitol in a dog.
J Vet Emerg Crit Care (San Antonio)
November 2024
The Animal Referral Centre, Auckland, New Zealand.
Objective: To describe a case of a suspected anaphylactoid reaction to mannitol in a dog.
Case Summary: A 1-year-old, neutered female French Bulldog was anesthetized for a T12-T13 dorsal laminectomy surgery for a previously diagnosed spinal arachnoid diverticulum. Perioperatively, the spinal cord appeared grossly edematous, and IV mannitol administration was elected.
Valsartan/Sacubitril induced isolated angioedema of uvula: A case report.
Heliyon
November 2024
Department of Radiology, Ibn Sina Specialized Hospital, Jenin, P200, Palestine.
Objective: To report a case of drug-induced isolated angioedema secondary to the use of Entresto (Valsartan/Sacubitril).
Case Summary: A 75-year-old White man presented with swelling of the uvula with a normal tongue shape and gradual onset of speech difficulty, shortness of breath, and difficulty swallowing after taking his chronic medication Entresto (sacubitril/valsartan). The main possibility considered was uvular angioedema, other potential causes were not identified.
Venom-induced myocarditis: An unusual case attributable to Vipera aspis bite.
Toxicon
November 2024
Division of Cardiology, SS Trinita' Borgomanero Hospital, ASL NO, Novara, Italy.
Article Synopsis
- Venomous snake bites, like those from the Vipera aspis, can lead to serious medical emergencies, including rare cardiovascular issues, and require immediate treatment.
- A case study of a 33-year-old reptile zoo keeper shows severe complications after a viper bite, including angioedema, severe thrombocytopenia, anemia, and compartment syndrome, necessitating surgical intervention and supportive transfusions.
- The patient also experienced cardiac issues such as low blood pressure and myocarditis, confirmed by echocardiography and MRI, highlighting the need for early identification and treatment of uncommon complications from snake bites with antivenom.
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