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Quantitative analysis of Δ- and Δ-tetrahydrocannabinol metabolites and isomers: a rapid assay in urine by LC-MS/MS.
Anal Bioanal Chem
January 2025
Department of Pathology, Immunology and Laboratory Medicine, University of Florida College of Medicine, Gainesville, FL, USA.
An increasing number of cannabis-related products have become available and entered the market, particularly those containing cannabidiol (CBD) and Δ-tetrahydrocannabinol (Δ-THC). Analytical methods for cannabinoids in urine have been described extensively in the literature. However, methods providing good resolution for distinguishing interferences from THC positional isomers are needed.
View Article and Find Full Text PDFSelective sensing of terbinafine hydrochloride using carbon-based electrodes: a green and sustainable electroanalytical method for pharmaceutical products.
Anal Methods
January 2025
ampere - Laboratório de Plataformas Eletroquímicas - Universidade Federal de Santa Catarina, Departamento de Química, 88040-900 Florianópolis, SC, Brazil.
Terbinafine hydrochloride (TBF) is a broad-spectrum antifungal used to treat various dermatophyte infections affecting the skin, hair, and nails. Accurate, sensitive, and affordable analytical methods are crucial for quantifying this drug. In this study, we report on the use of carbon-based electrodes for the electrochemical determination of TBF in pharmaceutical samples, including raw materials and tablets.
View Article and Find Full Text PDFIn silico optimization of a challenging bispecific antibody chromatography step.
Biotechnol Prog
January 2025
Automation, Digital and Learning Solutions, Cytiva, Karlsruhe, Germany.
Mechanistic modeling of chromatographic steps is an effective tool in biopharma process development that enhances process understanding and accelerates optimization efforts and subsequent risk assessment. A relatively new model for ion exchange chromatography is the colloidal particle adsorption (CPA) formalism, which promises improved separation of material and molecule-specific parameters. This case study demonstrates a straightforward CPA modeling workflow to describe an ion exchange chromatography polishing step of a knobs-into-holes construct bispecific antibody molecule.
View Article and Find Full Text PDFCombination of atom transfer radical polymerization and alkyne-azide click-chemistry for the synthesis of phosphonic acid cation exchange materials.
J Chromatogr A
January 2025
Faculty of Chemistry, Analytical Chemistry, University of Marburg, Hans-Meerwein-Str. 4, Marburg 35043, Germany. Electronic address:
Phosphonic acid cation exchange materials (PCX) are synthesized by atom transfer radical polymerization (ATRP) followed by alkyne-azide click-chemistry. ATRP is used to synthesize polymeric chains of diethyl 4-vinylbenzylphosphonate with different chain lengths, which are covalently bonded to the surface of monodisperse polystyrene-divinylbenzene (PS/DVB) particles by click-chemistry. The functionalized particles are characterized by FIB-SEM, IR and Schoeniger combustion followed by chromatographic experiments.
View Article and Find Full Text PDFDevelopment and Application of a Comprehensive Non-targeted Screening Strategy for Fentanyl Analogues.
J Hazard Mater
January 2025
Chengdu Institute of Biology, Chinese Academy of Sciences, Chengdu 610213, China; Key Laboratory of Monitoring and Assessment on Novel Food Raw Materials, State Administration for Market Regulation, Chengdu 611130, China. Electronic address:
The growing abuse of fentanyl and its analogues (FTNs) presents a substantial public health threat, prompting the introduction of regulatory controls by government authorities. Nevertheless, existing screening strategies for FTNs are primarily based on targeted or non-targeted approaches that utilize a limited set of mass spectrometry fragmentation data, which are far from meeting the needs of class scheduling. In this study, a comprehensive non-targeted screening strategy for FTNs was developed.
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