A quinoline-based ligand was shown to promote palladium-catalyzed β-C(sp(3))-H fluorination for the first time. A range of unnatural enantiopure fluorinated α-amino acids were obtained through sequential β-C(sp(3))-H arylation and subsequent stereoselective fluorination from readily available L-alanine.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4934178 | PMC |
| http://dx.doi.org/10.1021/jacs.5b04088 | DOI Listing |
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