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Natural Teeth for Prosthetic Solutions in Pediatric Patients: Two Case Reports of Biologically Based Removable Functional Partial Dentures.
Cureus
September 2024
Department of Pedodontics and Preventive Dentistry, Hitkarini Dental College and Hospital, Jabalpur, IND.
Prosthetic appliances are essential for promoting the proper development of teeth, dental arches, and facial bones in children. Due to the constantly changing nature of a child's oral environment, these appliances must be temporary and require regular maintenance and adjustment to avoid impeding orofacial growth. A fundamental aspect of contemporary dentistry is re-establishing aesthetics.
View Article and Find Full Text PDFNew therapeutic avenues in multiple sclerosis: Is there a place for gut microbiota-based treatments?
Pharmacol Res
November 2024
Department of Drug Sciences, Section of Pharmacology, University of Pavia, Pavia, Italy. Electronic address:
Article Synopsis
- The gut microbiota-brain axis connects gut health to brain function, potentially influencing neurodegenerative diseases, particularly multiple sclerosis (MS).
- MS is characterized by gastrointestinal issues and an altered gut microbiome compared to healthy individuals, which may worsen disease symptoms and progression.
- The review discusses various dietary and microbiota-based interventions aimed at restoring gut health, which could help prevent or manage MS through symptom relief and slowing disease progression.
Communication in disasters to support families with children with medical complexity and special healthcare needs: a rapid scoping review.
Front Public Health
March 2024
Complex Care Program, British Columbia Children's Hospital, Vancouver, BC, Canada.
Disasters can disrupt normal healthcare processes, with serious effects on children who depend upon regular access to the health care system. Children with medical complexity (CMC) are especially at risk. These children have chronic medical conditions, and may depend on medical technology, like feeding tubes.
View Article and Find Full Text PDFThe ubiquitin-conjugating enzyme UBE2D/eff maintains a youthful proteome and ensures protein quality control during aging.
bioRxiv
February 2024
Department of Developmental Neurobiology, St. Jude Children's Research Hospital, Memphis, TN 38105, USA.
Ubiquitin-conjugating enzymes (E2s) are key for regulating protein function and turnover via ubiquitination but it remains undetermined which E2s maintain proteostasis during aging. Here, we find that E2s have diverse roles in handling a model aggregation-prone protein (huntingtin-polyQ) in the retina: while some E2s mediate aggregate assembly, UBE2D/effete (eff) and other E2s are required for huntingtin-polyQ degradation. UBE2D/eff is key for proteostasis also in skeletal muscle: eff protein levels decline with aging, and muscle-specific eff knockdown causes an accelerated buildup in insoluble poly-ubiquitinated proteins (which progressively accumulate with aging) and shortens lifespan.
View Article and Find Full Text PDFCholangioscopic recanalization of a completely obstructed anastomotic biliary stricture after liver transplant.
VideoGIE
December 2023
Department of Gastroenterology and Hepatology, UNC Hospitals, Chapel Hill, North Carolina.
Article Synopsis
- A 51-year-old woman underwent a liver transplant and later developed clinical biliary pancreatitis due to a severe stricture at the surgical anastomosis site.
- After initial efforts to relieve the stricture via ERCP and stenting failed, repeated complications arose with obstructive biliary disease and stricturing attributed to fibrosis and ischemia.
- Subsequent attempts at treatment included antegrade recanalization and, ultimately, retrograde cholangioscopy with a specialized endoscope, although successful passage through the stricture remained elusive.
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