Objective: To determine serum soluble CD30 (sCD30) levels in patients with graft versus host disease (GVHD).
Methods: Serum soluble CD30 levels and IgE levels were assayed by a sensitive ELISA in 57 patients with bone marrow transplantation, and in 44 healthy controls. We analyzed the type of effector T cells in patients with GVHD.
Results: Serum levels of sCD30 and serum IgE levels were significantly higher (p values <0.05) in patients with acute and chronic GVHD than in healthy controls. We found that CD30(+) T-cells are present in the skin of patients with GVHD.
Conclusion: These results suggest that serum sCD30 levels may be helpful for the management of patients with bone marrow transplantation.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4389013 | PMC |
| http://dx.doi.org/10.1007/s13317-013-0054-7 | DOI Listing |
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