AI Article Synopsis
- In nuclear medicine, workers handle radioactive materials like (18)FDG, which is crucial for PET/CT imaging but difficult to monitor due to its short half-life.
- The authors created a new in vitro bioassay method using spot urine samples to estimate internal exposure without needing a 24-hour urine collection, alongside developing biokinetic models for (18)FDG.
- This new methodology is expected to improve internal monitoring for workers with short-lived radionuclides across various fields, especially in nuclear medicine.
Article Abstract
In nuclear medicine, workers handle unsealed radioactive materials. Among the materials, (18)FDG is the most widely used in PET/CT technique. Because of the short half-life of (18)F, it is very challenging to monitor internal exposure of nuclear medicine workers using in vitro bioassay. Thus, the authors developed the new in vitro bioassay methodology for short half-life nuclides. In the methodology, spot urine sample is directly used without normalisation to 1-d urine sample and the spot urinary excretion function was newly proposed. In order to estimate the intake and committed dose for workers dealing (18)FDG, biokinetic models for FDG was also developed. Using the new methodology and biokinetic model, the in vitro bioassay for workers dealing (18)FDG was successfully performed. The authors expect that this methodology will be very useful for internal monitoring of workers who deal short-lived radionuclides in the all field as well as the nuclear medicine field.
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| http://dx.doi.org/10.1093/rpd/ncv346 | DOI Listing |
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