Genetic encoding of the post-translational modification 2-hydroxyisobutyryl-lysine.

Org Biomol Chem

Department of Chemistry, Virginia Commonwealth University, 1001 W. Main Street, Richmond, Virginia 23284, USA.

Published: June 2015

We report the synthesis and genetic encoding of a recently discovered post-translational modification, 2-hydroxyisobutyryl-lysine, to the genetic code of E. coli. The production of homogeneous proteins containing this amino acid will facilitate the study of modification in full-length proteins.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4457286PMC
http://dx.doi.org/10.1039/c5ob00283dDOI Listing

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