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Metastatic olfactory neuroblastoma with unusual solitary metastasis to femur: a case report and literature review.
World J Surg Oncol
March 2025
Department of Orthopedic Surgery, College of Medicine, King Saud University, Riyadh, Saudi Arabia.
Background: Olfactory neuroblastoma (ONB) is a rare malignancy that develops in the nasal cavity, with appendicular skeletal metastases being exceptionally uncommon. We report the case of a middle-aged male with ONB, presenting with an unusual biopsy-confirmed solitary metastasis to the left proximal femur.
Case Presentation: A 33-year-old male was previously diagnosed with olfactory neuroblastoma in the skull base after initial clinical presentation with progressive left-sided nasal obstruction for six months.
Berberine-inspired ionizable lipid for self-structure stabilization and brain targeting delivery of nucleic acid therapeutics.
Nat Commun
March 2025
Engineering Research Center of Coptis Development & Utilization, Ministry of Education, College of Pharmaceutical Sciences, Southwest University, Chongqing, 400715, PR China.
Lipid nanoparticles have shown success in targeting major organs such as the liver, spleen, and lungs, but crossing the blood-brain barrier (BBB) remains a major challenge. Effective brain-targeted delivery systems are essential for advancing gene therapy for neurological diseases but remain limited by low transport efficiency and poor nucleic acid stability. Here, we report a library of ionizable lipids based on the tetrahydroisoquinoline structure of protoberberine alkaloids, designed to improve BBB penetration via dopamine D3 receptor-mediated endocytosis.
View Article and Find Full Text PDFTargeting EGFR and PI3K/mTOR pathways in glioblastoma: innovative therapeutic approaches.
Med Oncol
March 2025
Neuropharmacology Division, Department of Pharmacology, ISF College of Pharmacy (an Autonomous College), Moga, Punjab, 142001, India.
Glioblastoma (GBM) stands as the most aggressive form of primary brain cancer in adults, characterized by its rapid growth, invasive nature, and a robust propensity to induce angiogenesis, forming new blood vessels to sustain its expansion. GBM arises from astrocytes, star-shaped glial cells, and despite significant progress in understanding its molecular mechanisms, its prognosis remains grim. It is frequently associated with mutations or overexpression of the epidermal growth factor receptor (EGFR), which initiates several downstream signaling pathways.
View Article and Find Full Text PDFA systematic review of high-grade glioma associated with Li-Fraumeni syndrome.
Neurosurg Rev
March 2025
Department of Neurosurgery, Allegheny Health Network Neuroscience Institute, Pittsburgh, PA, US.
Li-Fraumeni Syndrome (LFS) is a rare hereditary cancer syndrome characterized by an increased risk of early-onset and multiple tumors across various organ systems, predominantly linked to germline TP53 mutations. While commonly associated neoplasms include sarcomas, breast cancer, and adrenocortical carcinoma, the occurrence of high-grade gliomas (HGG), including glioblastoma multiforme (GBM), in LFS patients is less documented and typically presents at a younger age relative to sporadic cases. A systematic review following PRISMA guidelines was conducted, focusing on clinical studies and case reports that explore the association between HGG and LFS.
View Article and Find Full Text PDFGlobal health inequities in retinoblastoma: a 1990-2021 analysis across socio-demographic index regions.
Front Public Health
March 2025
Shanxi Eye Hospital Affiliated to Shanxi Medical University, Taiyuan, China.
Objective: To assess health inequities associated with retinoblastoma across various Socio-Demographic Index (SDI) regions and evaluate whether these inequities have decreased from 1990 to 2021, with the aim of enhancing awareness and guiding government policies.
Design: Population-based demographic analysis.
Participants: Children diagnosed with retinoblastoma from 204 countries and territories.
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