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Intertwined destinies - Acute ischemic stroke and neurogenic stress cardiomyopathy.
J Stroke Cerebrovasc Dis
January 2025
Department of Cardiology, Haemostaseology and Medical Intensive Care, University Medical Center Mannheim (UMM), Medical Faculty Mannheim, Heidelberg University, German Center for Cardiovascular Research (DZHK) Partner Site Heidelberg/Mannheim, Mannheim, Germany. Electronic address:
Sex differences and clinical outcomes, including ventricular tachyarrhythmias, of patients with heart failure with reduced ejection fraction treated with sacubitril/valsartan.
Front Cardiovasc Med
December 2024
Department of Cardiology, Angiology, Haemostaseology and Medical Intensive Care, Medical Faculty Mannheim, University Medical Center Mannheim, Heidelberg University, Mannheim, Germany.
Background: Women with heart failure with reduced ejection fraction (HFrEF) often experience worse clinical outcomes compared to men, including higher rates of mortality, hospitalization, and congestion. However, the effects of sacubitril/valsartan on these outcomes, as well as on ventricular tachyarrhythmias, have not been well studied in women with HFrEF.
Methods: This study included consecutive series of patients treated with sacubitril/valsartan at University Hospital Mannheim from 2016 to 2020.
Acute myocardial infarction (MI) is a leading cause of death worldwide. Although with current treatment, acute mortality from MI is low, the damage and remodeling associated with MI are responsible for subsequent heart failure. Reducing cell death associated with acute MI would decrease the mortality associated with heart failure.
View Article and Find Full Text PDFNuclear receptor 4A1 Regulates Mitochondrial Homeostasis in Cardiac Post-Ischemic Injury by Controlling Mitochondrial Fission 1 Protein-Mediated Fragmentation and Parkin-Dependent Mitophagy.
Int J Biol Sci
January 2025
Department of Cardiovascular Surgery, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou, China 510120.
Article Synopsis
- Mitochondrial fission and mitophagy are crucial for understanding myocardial ischemia-reperfusion (IR) injury, but their regulatory mechanisms are not well understood.
- Elevated Nr4a1 levels after myocardial IR injury correlate with worse cardiac function, increased cell death, inflammation, and endothelial issues, while Nr4a1-knockout mice show protection and better mitochondrial health.
- Targeting Nr4a1 to balance mitochondrial fission and mitophagy could provide new therapeutic options to improve heart health during ischemic conditions.
Pre-excitation alternans in a cat.
J Vet Cardiol
December 2024
Veterinary Specialty and Emergency Center of Thousand Oaks, 2967 North Moorpark Road, Thousand Oaks, CA 91360, USA.
A nine-year-old male neutered domestic shorthair cat presented on referral for evaluation. The cat presented to its primary veterinarian for acute onset vomiting, panting, and weakness. An electrocardiogram performed at the regular veterinarian was concerning for ventricular tachycardia, and the cat was referred for further evaluation.
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