Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4431412 | PMC |
| http://dx.doi.org/10.11604/pamj.2015.20.14.5382 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Gut microbiome and obesity in late adolescence: a case-control study in "Children of 1997" birth cohort.
Ann Epidemiol
December 2024
School of Public Health, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong Special Administrative Region, PR China.
Purpose: Although the gut microbiome is important in human health, its relation to adolescent obesity remains unclear. Here we assessed the associations of the gut microbiome with adolescent obesity in a case-control study.
Methods: In the "Children of 1997" birth cohort, participants with and without obesity at ~17.
Resolving the two-body problem: A postulated role for the V0 sector of the V0V1-ATPase in exosome biogenesis and multivesicular body fate.
Mol Biol Cell
January 2025
Department of Cell Biology and Physiology, Washington University School of Medicine, St. Louis, MO.
Because the discovery of the multivesicular body (MVB) as the origin of secreted vesicles or exosomes, the question arose and still looms-what distinguishes an MVB destined for fusion with the plasma membrane (EXO-MVB) facilitating exosome release from an MVB involved in transport of content to the lysosome (LYSO-MVB). Do they have independent origins? Hence, the two-body problem. We hypothesize that a key to this conundrum is the membrane spanning V0 sector of the proton pump, V0V1-ATPase.
View Article and Find Full Text PDFLate-Stage Reshaping of Phage-Displayed Libraries to Macrocyclic and Bicyclic Landscapes using a Multipurpose Linchpin.
J Am Chem Soc
December 2024
Department of Chemistry, University of Alberta, Edmonton, AB T6G 2G2, Canada.
Genetically encoded libraries (GEL) are increasingly being used for the discovery of ligands for "undruggable" targets that cannot be addressed with small molecules. Foundational GEL platforms like phage-, yeast-, ribosome-, and mRNA-display have enabled the display of libraries composed of 20 natural amino acids (20AA). Unnatural amino acids (UAA) and chemical post-translational modification (cPTM) expanded GEL beyond the 20AA space to yield unnatural linear, cyclic, and bicyclic peptides.
View Article and Find Full Text PDFHuman Exposure to Asbestos in Central Asian Countries and Health Effects: A Narrative Review.
Med Lav
December 2024
Department of Health Sciences; Course of Research Doctorate in Public Health Sciences, University of Milan, Milan, Italy/Occupational Health Unit, Santi Paolo e Carlo Hospital, Milan, Italy.
The discovery of the detrimental effects of asbestos on human health came long after its widespread use, with the first scientific evidence of asbestos-related diseases emerging in the late 19th and early 20th centuries. Despite efforts to ban its use, asbestos continues to be mined and used in Central Asia (as well as in Russia, China, and other countries). To gain a deeper understanding of the situation in Central Asia, we have conducted a systematic review of scientific literature on the use of asbestos, exposure assessment, and health consequences of asbestos exposure in this geographic area.
View Article and Find Full Text PDFAdvancing diagnosis and early risk assessment of preeclampsia through noninvasive cell-free DNA methylation profiling.
Clin Epigenetics
December 2024
Center for Medical Genetics, Ghent University Hospital, Ghent, Belgium.
Background: Aberrant embryo implantation and suboptimal placentation can lead to (severe) complications such as preeclampsia and fetal growth restriction later in pregnancy. Current identification of high-risk pregnancies relies on a combination of risk factors, biomarkers, and ultrasound examinations, a relatively inaccurate approach. Previously, aberrant DNA methylation due to placental hypoxia has been identified as a potential marker of placental insufficiency and, hence, potential (future) pregnancy complications.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!