Background: Pressure ulcers, also known as bedsores, decubitus ulcers and pressure injuries, are localised areas of injury to the skin or the underlying tissue, or both. Dressings are widely used to treat pressure ulcers and there are many options to choose from including alginate dressings. A clear and current overview of current evidence is required to facilitate decision-making regarding dressing use for the treatment of pressure ulcers. This review is part of a suite of Cochrane reviews investigating the use of dressings in the treatment of pressure ulcers. Each review will focus on a particular dressing type.
Objectives: To assess the effects of alginate dressings for treating pressure ulcers in any care setting.
Search Methods: For this review, in April 2015 we searched the following databases the Cochrane Wounds Group Specialised Register; The Cochrane Central Register of Controlled Trials (CENTRAL) (The Cochrane Library); Ovid MEDLINE; Ovid MEDLINE (In-Process & Other Non-Indexed Citations); Ovid EMBASE; and EBSCO CINAHL. There were no restrictions based on language or date of publication.
Selection Criteria: Published or unpublished randomised controlled trials (RCTs) comparing the effects of alginate with alternative wound dressings or no dressing in the treatment of pressure ulcers (stage II or above).
Data Collection And Analysis: Two review authors independently performed study selection, risk of bias assessment and data extraction.
Main Results: We included six studies (336 participants) in this review; all studies had two arms. The included studies compared alginate dressings with six other interventions that included: hydrocolloid dressings, silver containing alginate dressings, and radiant heat therapy. Each of the six comparisons included just one study and these had limited participant numbers and short follow-up times. All the evidence was of low or very low quality. Where data were available there was no evidence of a difference between alginate dressings and alternative treatments in terms of complete wound healing or adverse events.
Authors' Conclusions: The relative effects of alginate dressings compared with alternative treatments are unclear. The existing trials are small, of short duration and at risk of bias. Decision makers may wish to consider aspects such as cost of dressings and the wound management properties offered by each dressing type, for example, exudate management.
Download full-text PDF |
Source |
---|---|
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10555387 | PMC |
http://dx.doi.org/10.1002/14651858.CD011277.pub2 | DOI Listing |
Int J Biol Macromol
December 2024
Department of Pharmaceutics, School of Pharmacy, China Medical University, No.77 Puhe Road, Shenyang North New Area, Shenyang 110122, China. Electronic address:
Sonodynamic therapy is an emerging therapeutic approach for combating bacterial infections. However, the characteristics of hypoxia, high HO microenvironment, and the formation of persistent biofilms in diabetic wound sites limit its efficacy in this field. To address these issues, we developed a multifunctional antibacterial hydrogel dressing PPCN@Pt-AMPs/HGel with the cross-linked gelatin and sodium alginate as the matrix, where the nanosonosensitizer PCN-224 was decorated with the oxygen-generating Pt nanoenzyme and further coupled with a biofilm-targeting antimicrobial peptide via an interacting polydopamine layer.
View Article and Find Full Text PDFInt J Biol Macromol
December 2024
Division of Colorectal Surgery, Department of Surgery, Tehran University of medical sciences, Tehran, Iran.
This study addresses the limitations of traditional antibiotic treatments for burn wound dressings, which often lead to microbial resistance. It explores the development of innovative burn wound dressings by incorporating Zeolitic Imidazolate Framework-8 (ZIF-8) into alginate-gelatin (Al-Gl) hydrogels on gauze. Al-Gl patches with 0 %, 1 %, and 4 % ZIF-8 were fabricated and characterized using XRD, FTIR, FESEM, and EDX.
View Article and Find Full Text PDFBioprocess Biosyst Eng
December 2024
Chemical Sciences, Faculty of Science, Universiti Brunei Darussalam, Jalan Tungku Link, Gadong, BE 1410, Brunei Darussalam.
In recent years, zinc oxide nanoparticles (ZnO NPs) have gained much attention in biomedical applications because of their distinctive physicochemical features such as low toxicity and biocompatible properties. Traditional methods to produce ZnO NPs sometimes include harmful substances and considerable energy consumption, causing environmental issues and potential health risks. Nowadays, the concern of ZnO production has moved toward environmentally friendly and sustainable synthesis methods, using natural extracts or plant-based precursors.
View Article and Find Full Text PDFEur J Pharm Biopharm
December 2024
Department of Biomedical Engineering, Indian Institute of Technology (IIT), Hyderabad, India. Electronic address:
Skin, as the primary interface with the external environment, is susceptible to damage, posing a formidable challenge for complete restoration in adult skin injuries. Wound healing remains a clinical challenge, necessitating advanced biomaterials to support cell proliferation, modulate inflammation, and combat infections. Among several options, hydrogel can be a capable contender for biological dressings.
View Article and Find Full Text PDFInt J Biol Macromol
December 2024
School of Physics and Electronic Information, Yan'an University, Yan'an 716000, China; Shaanxi Key Laboratory of Intelligent Processing for Big Energy Data, Yan'an 716000, China.
With the global emphasis on green and sustainable development, sodium alginate-based hydrogels (SAHs), as a renewable and biocompatible environmental material, have garnered widespread attention for their research and application. This review summarizes the latest advancements in the study of SAHs, thoroughly discussing their structural characteristics, formation mechanisms, and current applications in various fields, as well as prospects for future development. Initially, the chemical structure of SA and the network structure of hydrogels are introduced, and the impact of factors such as molecular weight, crosslinking density, and environmental conditions on the hydrogel structure is explored.
View Article and Find Full Text PDFEnter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!