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Role of sirtuin 1 in depression‑induced coronary heart disease: Molecular pathways and therapeutic potential (Review).
Biomed Rep
March 2025
Department of Cardiology, Affiliated Renhe Hospital of China Three Gorges University, Yichang, Hubei 443001, P.R. China.
Depression and coronary heart disease (CHD) are two interconnected diseases that profoundly impact global health. Depression is both a complex psychiatric disorder and an established risk factor for CHD. Sirtuin 1 (SIRT1) is an enzyme that requires the cofactor nicotinamide adenine dinucleotide (NAD) to perform its deacetylation function, and its involvement is crucial in reducing cardiovascular risks that are associated with depression.
View Article and Find Full Text PDFEngineered heart muscle allografts for heart repair in primates and humans.
Nature
January 2025
German Centre for Cardiovascular Research (DZHK), Partner Site Lower Saxony, Göttingen, Germany.
Cardiomyocytes can be implanted to remuscularize the failing heart. Challenges include sufficient cardiomyocyte retention for a sustainable therapeutic impact without intolerable side effects, such as arrhythmia and tumour growth. We investigated the hypothesis that epicardial engineered heart muscle (EHM) allografts from induced pluripotent stem cell-derived cardiomyocytes and stromal cells structurally and functionally remuscularize the chronically failing heart without limiting side effects in rhesus macaques.
View Article and Find Full Text PDFPreexisting multimorbidity predicts greater mortality risks related to long-term PM exposure.
Environ Pollut
January 2025
Institute of Social Development and Health Management, Hubei Province Key Laboratory of Occupational Hazard Identification and Control, School of Public Health, Wuhan University of Science and Technology, Wuhan 430065, China. Electronic address:
Long-term health risk assessments related to ambient fine particulate matter (PM) exposure have been more limited to general population but not towards individuals suffering from multimorbidity. While both multimorbidity and PM are independently linked to elevated mortality risk, their combined effects and interactions remain practically unexplored. A cross-cohort analysis was undertaken on data from 3 prospective cohorts, initially enrolling 869038 adults aged ≥18 years followed up during 2005-2022.
View Article and Find Full Text PDFWhich Test is Best for Pain in the Chest?
R I Med J (2013)
February 2025
Professor of Medicine, Clinician Educator, Warren Alpert Medical School, Brown University; Associate Chief, Cardiology, Brown University Health Cardiovascular Institute, Providence, Rhode Island.
Chest pain is one of the most common chief complaints seen in both the emergency department (ED) and primary care settings.1,2 It is estimated that 20-40% of the general population will suffer from chest pain at some point throughout their lives.3 Interestingly although obstructive coronary artery disease (CAD) prevalence has declined, chest pain as a presenting symptom has become increasingly common over the last decade.
View Article and Find Full Text PDFCMRxRecon2024: A Multimodality, Multiview k-Space Dataset Boosting Universal Machine Learning for Accelerated Cardiac MRI.
Radiol Artif Intell
January 2025
Human Phenome Institute and Shanghai Pudong Hospital, Fudan University, Shanghai, China.
. The released CMRxRecon2024 dataset is currently the largest and most protocol-diverse publicly available k-space dataset including multi-modality and multi-view cardiac MRI data from 330 healthy volunteers, and each one covers standardized and commonly used clinical protocols. ©RSNA, 2025.
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