Intravenous injections to rabbits of perfluorocarbon emulsion containing perfluorodecaline (10 ml/kg, equivalent to 1.3 g of perfluorodecaline per 1 kg of body weight) produced a 2-4-fold increase of cytochrome P-450 content in the liver microsomes within 3-4 weeks. Cytochrome P-450 induction was followed by activation of the liver monoxygenase system evaluated by the rate of antipyrine excretion from the blood. On the 1st day after administration perfluorodecaline caused an insignificant (14%) inhibition of the monoxygenase system.
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