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Natural History of Symptoms in Patients With Esophagogastric Junction Outflow Obstruction Using Standardized Surveys.
Cureus
November 2024
Department of Medicine, Division of Gastroenterology and Hepatology, Penn State College of Medicine, Hershey, USA.
Background Our aim was to assess the clinical presentation and outcomes of patients with a manometric diagnosis of esophagogastric junction outflow obstruction (EGJOO) using standardized symptom surveys and comparison to a cohort who were referred for manometry but who had a normal study. Methods We followed a cohort of adult patients without a mechanical obstruction who underwent high-resolution manometry at our medical center from 9/12/19 to 10/4/21 for 16 months. Results Thirty-seven patients with EGJOO (age: 60.
View Article and Find Full Text PDFThe Impact of Bolus Rheology on Physiological Swallowing Parameters Derived by Pharyngeal High-Resolution Manometry Impedance.
Neurogastroenterol Motil
December 2024
Trisco Foods, Carole Park, Queensland, Australia.
Article Synopsis
- The study examines how the rheology (flow behavior) of ingested fluids affects swallowing and the physiological responses during deglutition, specifically comparing xanthan gum (XG) and sodium carboxymethylcellulose gum (CMC) in healthy adults.
- Results showed that CMC had significantly higher viscosity than XG at higher shear rates (300 s), leading to increased flow resistance during swallowing, indicated by higher intrabolus pressure and altered relaxation times of the upper esophageal sphincter (UES).
- The findings suggest that the differences in shear viscosity of these fluids affect pharyngeal function during swallowing, highlighting the importance of fluid properties over standardized viscosity levels (IDDSI).
Pre- and post-intervention oesophageal pressure topography metrics in the three subtypes of achalasia: A pilot study on Indian adults.
Med J Armed Forces India
December 2024
Consultant (Med & Gastroenterology), Command Hospital (Eastern Command), Kolkata, India.
Background: Achalasia is characterized by failure of relaxation of the lower oesophageal sphincter (LOS) and abnormal peristalsis during swallowing. The study aimed to observe the effects of intervention in three sub-types of achalasia and compare the intervention outcomes among the three sub-types.
Methods: Forty-one patients underwent Eckardt scoring for severity of achalasia, followed by high-resolution manometry (HRM).
Positive effect of erythromycin on ineffective oesophageal motility in laryngopharyngeal reflux patients: Room for a novel treatment?
Clin Physiol Funct Imaging
January 2025
Sydney Heartburn Clinic, Lindfield, New South Wales, Australia.
Introduction: Laryngopharyngeal reflux (LPR) management guidelines are currently derived from the management of gastroesophageal reflux disease (GORD) which has been shown to be poorly effective in controlling symptoms for these patients. Erythromycin is a macrolide antibiotic that has been used extensively as a prokinetic agent for the gastrointestinal tract. The management of LPR with prokinetics is a novel therapy being investigated with regard to its effectiveness.
View Article and Find Full Text PDFEsophageal Dysfunction in Immune Checkpoint Inhibitor-related Myositis: A Case Report.
Intern Med
December 2024
Department of Neurology, Gifu University Graduate School of Medicine, Japan.
A 69-year-old woman with left-sided breast cancer developed elevated creatine kinase levels and muscle weakness in her extremities after treatment with pembrolizumab. The patient was diagnosed with immune checkpoint inhibitor (ICI)-related myositis. Although the patient had no symptoms of dysphagia, we evaluated her swallowing function because esophageal dysfunction is a known complication of idiopathic inflammatory myopathy.
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