Two new strongylophorine derivatives, along with six known strongylophorines, were isolated from the marine sponge Petrosia corticata as proteasome inhibitors. Of these, a hemiacetal mixture of strongylophorines-13/-14 was the strongest inhibitor of the proteasome with an IC50 of 2.1μM.
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| http://dx.doi.org/10.1016/j.bmcl.2015.04.075 | DOI Listing |
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