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Efficacy of mannatide combined with sodium cantharidate vitamin B6 in the treatment of malignant pleural effusions. | LitMetric

AI Article Synopsis

  • The study aimed to assess the effectiveness of using mannatide combined with sodium cantharidate and vitamin B6 for treating malignant pleural effusions in patients not undergoing systemic chemotherapy.
  • In a trial with 69 patients, 37 received the new combination therapy, while 32 were given mannatide with cisplatin.
  • Results showed no significant difference in overall patient responses between groups, but the new treatment had better quality-of-life improvements and fewer side effects.

Article Abstract

Objective: To evaluate the efficacy of mannatide combined with sodium cantharidate vitamin B6 in the treatment of malignant pleural effusions.

Materials And Methods: Data for 69 patients with malignant pleural effusions who did not receive systemic chemotherapy were collected. Injection into the thorax using mannatide combined with sodium cantharidate vitamin B6 was performed for 37 patients in the experimental group and mannatide combined with cisplatin for 32 patients in the control group. Objective responses, KPS (Karnofsky Scoring) and incidences of side effects between the two groups were compared.

Results: 13 patients reached CR (complete response) and 11 PR (partial response) in the experimental group, while 12 patients reached CR and 9 PR in the control group, the difference in overall objective responses between the two groups not being significant (66.7% vs 63.6%, p=0.806). However, improvement of KPS in the experimental group was greater than in the control group; total side-effect incidences during the period of treatment were 22.2% (8/36) and 54.5% (18/33), respectively (p=0.006).

Conclusions: Regimen of mannatide combined with sodium cantharidate vitamin B6 had better improvement in quality-of-life and symptom relief, with a lower side-effect incidence in treatment of malignant pleural effusions.

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Source
http://dx.doi.org/10.7314/apjcp.2015.16.9.3913DOI Listing

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