AI Article Synopsis
- Bioactive pigments were extracted from Serratia marcescens and Chromobacterium violaceum, with prodigiosin and violacein identified as the main compounds.
- Research indicated that prodigiosin was more effective than violacein at inhibiting the growth of the parasites Plasmodium falciparum and Trypanosoma brucei gambiense in vitro.
- Combinations of prodigiosin with silver and gold nanoparticles significantly lowered the effective concentration needed to inhibit parasites while remaining non-toxic to mammalian cells, suggesting potential for drug development based on these pigments.
Article Abstract
Bioactive pigments were extracted and purified from cultures of Serratia marcescens and Chromobacterium violaceum. Spectroscopic, FTIR, and HPLC analyses showed prodigiosin and violacein as the principle molecules in the extract. Bioactive microbial pigments prodigiosin, violacein and their combinations with phytosynthesized silver and gold nanoparticles were studied for in vitro growth inhibition of Plasmodium falciparum and Trypanosoma brucei gambiense. Prodigiosin was found to be more effective than violacein for inhibition of both parasites in vitro. Specifically, combinations of the microbial pigment prodigiosin with metal nanoparticles showed a significant decrease in the IC50 values on both parasites (2.7 to 3.6 fold) without increase of cytotoxicity upon mammalian cells. The data may be useful for the microbial pigment based drug designing.
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| http://dx.doi.org/10.1016/j.parint.2015.05.004 | DOI Listing |
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