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Comprehensive three-dimensional microCT and signaling analysis reveal the teratogenic effect of 2,3,7,8-tetrachlorodibenzo-p-dioxin on craniofacial bone development in mice.
Ecotoxicol Environ Saf
January 2025
Department of Stomatology, the Affiliated Suzhou Hospital of Nanjing Medical University, Suzhou Municipal Hospital, Gusu School, Nanjing Medical University, No. 242, Guangji Road, Suzhou, Jiangsu Province 215000, China. Electronic address:
Exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) in utero can result in osteogenic defect during palatogenesis, but the effects on other craniofacial bones and underlying mechanisms remain to be characterized. By treating pregnant mice with TCDD (40 μg/kg) at the vital craniofacial patterning stages (embryonic day 8.5, 10.
View Article and Find Full Text PDFEffects of Atmospheric Pollutants on Volatile-Mediated Insect Ecosystem Services.
Glob Chang Biol
January 2025
Department of Environmental and Biological Sciences, Faculty of Science, Forestry and Technology, University of Eastern Finland, Kuopio, Finland.
Primary and secondary atmospheric pollutants, including carbon monoxide (CO), carbon dioxide (CO), nitrogen oxides (NO), ozone (O), sulphur dioxide (SO) and particulate matter (PM/PM) with associated heavy metals (HMs) and micro- and nanoplastics (MPs/NPs), have the potential to influence and alter interspecific interactions involving insects that are responsible for providing essential ecosystem services (ESs). Given that insects rely on olfactory cues for vital processes such as locating mates, food sources and oviposition sites, volatile organic compounds (VOCs) are of paramount importance in interactions involving insects. While gaseous pollutants reduce the lifespan of individual compounds that act as olfactory cues, gaseous and particulate pollutants can alter their biosynthesis and emission and exert a direct effect on the olfactory system of insects.
View Article and Find Full Text PDFSeizures and premature death in mice with targeted Kv1.1 deficiency in corticolimbic circuits.
Brain Commun
January 2025
Department of Biological Sciences, Southern Methodist University, Dallas, TX 75275, USA.
Sudden unexpected death in epilepsy (SUDEP) is the leading cause of epilepsy-related death, likely stemming from seizure activity disrupting vital brain centres controlling heart and breathing function. However, understanding of SUDEP's anatomical basis and mechanisms remains limited, hampering risk evaluation and prevention strategies. Prior studies using a neuron-specific conditional knockout mouse model of SUDEP identified the primary importance of brain-driven mechanisms contributing to sudden death and cardiorespiratory dysregulation; yet, the underlying neurocircuits have not been identified.
View Article and Find Full Text PDFUnveiling Cardiac Mysteries: The Role of Endomyocardial Biopsy in Diagnosing Heart Masses.
JACC Case Rep
January 2025
Department of Clinical Cardiology, Cleveland Clinic, Cleveland, Ohio, USA.
This case series highlights the role of endomyocardial biopsy (EMB) in diagnosing cardiac tumors instead of tumor resection. EMB provided critical diagnostic clarity and influenced therapeutic decisions, demonstrating its utility in complex cardiovascular cases while preventing unnecessary surgery. Furthermore, EMB provides vital information that can be used for a multidisciplinary approach to cardiac tumors.
View Article and Find Full Text PDFExercise improves body composition, physical fitness, and blood levels of C-peptide and IGF-1 in 11- to 12-year-old boys with obesity.
Front Physiol
January 2025
Institute of Sports and Arts Convergence, Inha University, Incheon, Republic of Korea.
Introduction: Exercise is vital in preventing and treating obesity. Despite its importance, the understanding of how exercise influences childhood obesity at the biochemical level is limited. In this study, we explore the effects of a 16-week exercise program (EP) on body composition, physical fitness, and the blood levels of hormones related to obesity.
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